Cargando…

Neuroendocrine carcinoma of the ovotestis: A case report and review of literatures

BACKGROUND: Neuroendocine carcinoma of the gynecologic tract is rare and poses a significant clinical challenge because of tumor heterogeneity and lack of standardized guidelines for treatment. Ovotestis refers to the histology of a gonad that contains both ovarian follicles and testicular tubular e...

Descripción completa

Detalles Bibliográficos
Autores principales: Ashrafganjoei, Tahereh, Sourati, Ainaz, Mohamadianamiri, Mahdiss
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research and Clinical Center for Infertility 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5203694/
https://www.ncbi.nlm.nih.gov/pubmed/28066838
_version_ 1782489772838617088
author Ashrafganjoei, Tahereh
Sourati, Ainaz
Mohamadianamiri, Mahdiss
author_facet Ashrafganjoei, Tahereh
Sourati, Ainaz
Mohamadianamiri, Mahdiss
author_sort Ashrafganjoei, Tahereh
collection PubMed
description BACKGROUND: Neuroendocine carcinoma of the gynecologic tract is rare and poses a significant clinical challenge because of tumor heterogeneity and lack of standardized guidelines for treatment. Ovotestis refers to the histology of a gonad that contains both ovarian follicles and testicular tubular elements. Ovotesticular disorder of sexual development occurs in fewer than 10% of all disorders of sexual development. Gonadal tumors with malignant potential occur in 2.6% of all cases of ovotesticular disorder of sexual development. CASE: Here we represent a 77-year-old woman with primary amenorrhea, infertility and 10cm solid mass in left adnex with 46 XY in karyotype with ovotestis neuroendocrine neoplasm in pathology report which was treated with a multi-modality manner including surgery and chemotherapy but she came back with pulmonary metastasis after 2 cycles of chemotherapy. For women who present with a stage 1 primary ovarian neuroendocrine tumor the prognosis is excellent with greater than 90% survival. Neuroendocrine tumor of the ovary represents 3 % of all neuroendocrine tumors. The prevalence of ovotestis is 1/20000 births. For women with more advanced disease, the prognosis is poor. Neuroendocrine carcinoma of the ovary is a rare and aggressive tumor commonly associated with other surface epithelial and germ cell neoplasms. The prevalence of ovotestis is 1/20000 births and gonadal malignancies are the most reported neoplasm affected the ovotestis. Here we report a case of ovotestis which is presented with neuroendocrine carcinoma and poor prognosis. CONCLUSION: Neuroendocrine carcinoma of the ovary is a rare and aggressive tumor commonly associated with other surface epithelial and germ cell neoplasms. The prevalence of ovotestis is rare and gonadal malignancies are the most reported neoplasm affected the ovotestis.
format Online
Article
Text
id pubmed-5203694
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Research and Clinical Center for Infertility
record_format MEDLINE/PubMed
spelling pubmed-52036942017-01-06 Neuroendocrine carcinoma of the ovotestis: A case report and review of literatures Ashrafganjoei, Tahereh Sourati, Ainaz Mohamadianamiri, Mahdiss Int J Reprod Biomed Case Report BACKGROUND: Neuroendocine carcinoma of the gynecologic tract is rare and poses a significant clinical challenge because of tumor heterogeneity and lack of standardized guidelines for treatment. Ovotestis refers to the histology of a gonad that contains both ovarian follicles and testicular tubular elements. Ovotesticular disorder of sexual development occurs in fewer than 10% of all disorders of sexual development. Gonadal tumors with malignant potential occur in 2.6% of all cases of ovotesticular disorder of sexual development. CASE: Here we represent a 77-year-old woman with primary amenorrhea, infertility and 10cm solid mass in left adnex with 46 XY in karyotype with ovotestis neuroendocrine neoplasm in pathology report which was treated with a multi-modality manner including surgery and chemotherapy but she came back with pulmonary metastasis after 2 cycles of chemotherapy. For women who present with a stage 1 primary ovarian neuroendocrine tumor the prognosis is excellent with greater than 90% survival. Neuroendocrine tumor of the ovary represents 3 % of all neuroendocrine tumors. The prevalence of ovotestis is 1/20000 births. For women with more advanced disease, the prognosis is poor. Neuroendocrine carcinoma of the ovary is a rare and aggressive tumor commonly associated with other surface epithelial and germ cell neoplasms. The prevalence of ovotestis is 1/20000 births and gonadal malignancies are the most reported neoplasm affected the ovotestis. Here we report a case of ovotestis which is presented with neuroendocrine carcinoma and poor prognosis. CONCLUSION: Neuroendocrine carcinoma of the ovary is a rare and aggressive tumor commonly associated with other surface epithelial and germ cell neoplasms. The prevalence of ovotestis is rare and gonadal malignancies are the most reported neoplasm affected the ovotestis. Research and Clinical Center for Infertility 2016-12 /pmc/articles/PMC5203694/ /pubmed/28066838 Text en http://creativecommons.org/licenses/by/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Ashrafganjoei, Tahereh
Sourati, Ainaz
Mohamadianamiri, Mahdiss
Neuroendocrine carcinoma of the ovotestis: A case report and review of literatures
title Neuroendocrine carcinoma of the ovotestis: A case report and review of literatures
title_full Neuroendocrine carcinoma of the ovotestis: A case report and review of literatures
title_fullStr Neuroendocrine carcinoma of the ovotestis: A case report and review of literatures
title_full_unstemmed Neuroendocrine carcinoma of the ovotestis: A case report and review of literatures
title_short Neuroendocrine carcinoma of the ovotestis: A case report and review of literatures
title_sort neuroendocrine carcinoma of the ovotestis: a case report and review of literatures
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5203694/
https://www.ncbi.nlm.nih.gov/pubmed/28066838
work_keys_str_mv AT ashrafganjoeitahereh neuroendocrinecarcinomaoftheovotestisacasereportandreviewofliteratures
AT souratiainaz neuroendocrinecarcinomaoftheovotestisacasereportandreviewofliteratures
AT mohamadianamirimahdiss neuroendocrinecarcinomaoftheovotestisacasereportandreviewofliteratures