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Nanostructured scaffold as a determinant of stem cell fate
The functionality of stem cells is tightly regulated by cues from the niche, comprising both intrinsic and extrinsic cell signals. Besides chemical and growth factors, biophysical signals are important components of extrinsic signals that dictate the stem cell properties. The materials used in the f...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5203716/ https://www.ncbi.nlm.nih.gov/pubmed/28038681 http://dx.doi.org/10.1186/s13287-016-0440-y |
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author | Krishna, Lekshmi Dhamodaran, Kamesh Jayadev, Chaitra Chatterjee, Kaushik Shetty, Rohit Khora, S. S. Das, Debashish |
author_facet | Krishna, Lekshmi Dhamodaran, Kamesh Jayadev, Chaitra Chatterjee, Kaushik Shetty, Rohit Khora, S. S. Das, Debashish |
author_sort | Krishna, Lekshmi |
collection | PubMed |
description | The functionality of stem cells is tightly regulated by cues from the niche, comprising both intrinsic and extrinsic cell signals. Besides chemical and growth factors, biophysical signals are important components of extrinsic signals that dictate the stem cell properties. The materials used in the fabrication of scaffolds provide the chemical cues whereas the shape of the scaffolds provides the biophysical cues. The effect of the chemical composition of the scaffolds on stem cell fate is well researched. Biophysical signals such as nanotopography, mechanical forces, stiffness of the matrix, and roughness of the biomaterial influence the fate of stem cells. However, not much is known about their role in signaling crosstalk, stem cell maintenance, and directed differentiation. Among the various techniques for scaffold design, nanotechnology has special significance. The role of nanoscale topography in scaffold design for the regulation of stem cell behavior has gained importance in regenerative medicine. Nanotechnology allows manipulation of highly advanced surfaces/scaffolds for optimal regulation of cellular behavior. Techniques such as electrospinning, soft lithography, microfluidics, carbon nanotubes, and nanostructured hydrogel are described in this review, along with their potential usage in regenerative medicine. We have also provided a brief insight into the potential signaling crosstalk that is triggered by nanomaterials that dictate a specific outcome of stem cells. This concise review compiles recent developments in nanoscale architecture and its importance in directing stem cell differentiation for prospective therapeutic applications. |
format | Online Article Text |
id | pubmed-5203716 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-52037162017-01-03 Nanostructured scaffold as a determinant of stem cell fate Krishna, Lekshmi Dhamodaran, Kamesh Jayadev, Chaitra Chatterjee, Kaushik Shetty, Rohit Khora, S. S. Das, Debashish Stem Cell Res Ther Review The functionality of stem cells is tightly regulated by cues from the niche, comprising both intrinsic and extrinsic cell signals. Besides chemical and growth factors, biophysical signals are important components of extrinsic signals that dictate the stem cell properties. The materials used in the fabrication of scaffolds provide the chemical cues whereas the shape of the scaffolds provides the biophysical cues. The effect of the chemical composition of the scaffolds on stem cell fate is well researched. Biophysical signals such as nanotopography, mechanical forces, stiffness of the matrix, and roughness of the biomaterial influence the fate of stem cells. However, not much is known about their role in signaling crosstalk, stem cell maintenance, and directed differentiation. Among the various techniques for scaffold design, nanotechnology has special significance. The role of nanoscale topography in scaffold design for the regulation of stem cell behavior has gained importance in regenerative medicine. Nanotechnology allows manipulation of highly advanced surfaces/scaffolds for optimal regulation of cellular behavior. Techniques such as electrospinning, soft lithography, microfluidics, carbon nanotubes, and nanostructured hydrogel are described in this review, along with their potential usage in regenerative medicine. We have also provided a brief insight into the potential signaling crosstalk that is triggered by nanomaterials that dictate a specific outcome of stem cells. This concise review compiles recent developments in nanoscale architecture and its importance in directing stem cell differentiation for prospective therapeutic applications. BioMed Central 2016-12-30 /pmc/articles/PMC5203716/ /pubmed/28038681 http://dx.doi.org/10.1186/s13287-016-0440-y Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Review Krishna, Lekshmi Dhamodaran, Kamesh Jayadev, Chaitra Chatterjee, Kaushik Shetty, Rohit Khora, S. S. Das, Debashish Nanostructured scaffold as a determinant of stem cell fate |
title | Nanostructured scaffold as a determinant of stem cell fate |
title_full | Nanostructured scaffold as a determinant of stem cell fate |
title_fullStr | Nanostructured scaffold as a determinant of stem cell fate |
title_full_unstemmed | Nanostructured scaffold as a determinant of stem cell fate |
title_short | Nanostructured scaffold as a determinant of stem cell fate |
title_sort | nanostructured scaffold as a determinant of stem cell fate |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5203716/ https://www.ncbi.nlm.nih.gov/pubmed/28038681 http://dx.doi.org/10.1186/s13287-016-0440-y |
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