Geographic Population Structure in Epstein-Barr Virus Revealed by Comparative Genomics

Epstein-Barr virus (EBV) latently infects the majority of the human population and is implicated as a causal or contributory factor in numerous diseases. We sequenced 27 complete EBV genomes from a cohort of Multiple Sclerosis (MS) patients and healthy controls from Italy, although no variants showe...

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Detalles Bibliográficos
Autores principales: Chiara, Matteo, Manzari, Caterina, Lionetti, Claudia, Mechelli, Rosella, Anastasiadou, Eleni, Chiara Buscarinu, Maria, Ristori, Giovanni, Salvetti, Marco, Picardi, Ernesto, D’Erchia, Anna Maria, Pesole, Graziano, Horner, David S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Genome Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5203774/
https://www.ncbi.nlm.nih.gov/pubmed/27635051
http://dx.doi.org/10.1093/gbe/evw226
Descripción
Sumario:Epstein-Barr virus (EBV) latently infects the majority of the human population and is implicated as a causal or contributory factor in numerous diseases. We sequenced 27 complete EBV genomes from a cohort of Multiple Sclerosis (MS) patients and healthy controls from Italy, although no variants showed a statistically significant association with MS. Taking advantage of the availability of ∼130 EBV genomes with known geographical origins, we reveal a striking geographic distribution of EBV sub-populations with distinct allele frequency distributions. We discuss mechanisms that potentially explain these observations, and their implications for understanding the association of EBV with human disease.

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