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Staphylococcus capitis isolated from prosthetic joint infections

Further knowledge about the clinical and microbiological characteristics of prosthetic joint infections (PJIs) caused by different coagulase-negative staphylococci (CoNS) may facilitate interpretation of microbiological findings and improve treatment algorithms. Staphylococcus capitis is a CoNS with...

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Autores principales: Tevell, S., Hellmark, B., Nilsdotter-Augustinsson, Å., Söderquist, B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5203848/
https://www.ncbi.nlm.nih.gov/pubmed/27680718
http://dx.doi.org/10.1007/s10096-016-2777-7
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author Tevell, S.
Hellmark, B.
Nilsdotter-Augustinsson, Å.
Söderquist, B.
author_facet Tevell, S.
Hellmark, B.
Nilsdotter-Augustinsson, Å.
Söderquist, B.
author_sort Tevell, S.
collection PubMed
description Further knowledge about the clinical and microbiological characteristics of prosthetic joint infections (PJIs) caused by different coagulase-negative staphylococci (CoNS) may facilitate interpretation of microbiological findings and improve treatment algorithms. Staphylococcus capitis is a CoNS with documented potential for both human disease and nosocomial spread. As data on orthopaedic infections are scarce, our aim was to describe the clinical and microbiological characteristics of PJIs caused by S. capitis. This retrospective cohort study included three centres and 21 patients with significant growth of S. capitis during revision surgery for PJI between 2005 and 2014. Clinical data were extracted and further microbiological characterisation of the S. capitis isolates was performed. Multidrug-resistant (≥3 antibiotic groups) S. capitis was detected in 28.6 % of isolates, methicillin resistance in 38.1 % and fluoroquinolone resistance in 14.3 %; no isolates were rifampin-resistant. Heterogeneous glycopeptide-intermediate resistance was detected in 38.1 %. Biofilm-forming ability was common. All episodes were either early post-interventional or chronic, and there were no haematogenous infections. Ten patients experienced monomicrobial infections. Among patients available for evaluation, 86 % of chronic infections and 70 % of early post-interventional infections achieved clinical cure; 90 % of monomicrobial infections remained infection-free. Genetic fingerprinting with repetitive sequence-based polymerase chain reaction (rep-PCR; DiversiLab®) displayed clustering of isolates, suggesting that nosocomial spread might be present. Staphylococcus capitis has the potential to cause PJIs, with infection most likely being contracted during surgery or in the early postoperative period. As S. capitis might be an emerging nosocomial pathogen, surveillance of the prevalence of PJIs caused by S. capitis could be recommended.
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spelling pubmed-52038482017-01-13 Staphylococcus capitis isolated from prosthetic joint infections Tevell, S. Hellmark, B. Nilsdotter-Augustinsson, Å. Söderquist, B. Eur J Clin Microbiol Infect Dis Original Article Further knowledge about the clinical and microbiological characteristics of prosthetic joint infections (PJIs) caused by different coagulase-negative staphylococci (CoNS) may facilitate interpretation of microbiological findings and improve treatment algorithms. Staphylococcus capitis is a CoNS with documented potential for both human disease and nosocomial spread. As data on orthopaedic infections are scarce, our aim was to describe the clinical and microbiological characteristics of PJIs caused by S. capitis. This retrospective cohort study included three centres and 21 patients with significant growth of S. capitis during revision surgery for PJI between 2005 and 2014. Clinical data were extracted and further microbiological characterisation of the S. capitis isolates was performed. Multidrug-resistant (≥3 antibiotic groups) S. capitis was detected in 28.6 % of isolates, methicillin resistance in 38.1 % and fluoroquinolone resistance in 14.3 %; no isolates were rifampin-resistant. Heterogeneous glycopeptide-intermediate resistance was detected in 38.1 %. Biofilm-forming ability was common. All episodes were either early post-interventional or chronic, and there were no haematogenous infections. Ten patients experienced monomicrobial infections. Among patients available for evaluation, 86 % of chronic infections and 70 % of early post-interventional infections achieved clinical cure; 90 % of monomicrobial infections remained infection-free. Genetic fingerprinting with repetitive sequence-based polymerase chain reaction (rep-PCR; DiversiLab®) displayed clustering of isolates, suggesting that nosocomial spread might be present. Staphylococcus capitis has the potential to cause PJIs, with infection most likely being contracted during surgery or in the early postoperative period. As S. capitis might be an emerging nosocomial pathogen, surveillance of the prevalence of PJIs caused by S. capitis could be recommended. Springer Berlin Heidelberg 2016-09-29 2017 /pmc/articles/PMC5203848/ /pubmed/27680718 http://dx.doi.org/10.1007/s10096-016-2777-7 Text en © The Author(s) 2016 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Article
Tevell, S.
Hellmark, B.
Nilsdotter-Augustinsson, Å.
Söderquist, B.
Staphylococcus capitis isolated from prosthetic joint infections
title Staphylococcus capitis isolated from prosthetic joint infections
title_full Staphylococcus capitis isolated from prosthetic joint infections
title_fullStr Staphylococcus capitis isolated from prosthetic joint infections
title_full_unstemmed Staphylococcus capitis isolated from prosthetic joint infections
title_short Staphylococcus capitis isolated from prosthetic joint infections
title_sort staphylococcus capitis isolated from prosthetic joint infections
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5203848/
https://www.ncbi.nlm.nih.gov/pubmed/27680718
http://dx.doi.org/10.1007/s10096-016-2777-7
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