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Mitochondrial lipids in neurodegeneration

Mitochondrial dysfunction is a common feature of many neurodegenerative diseases, including proteinopathies such as Alzheimer’s or Parkinson’s disease, which are characterized by the deposition of aggregated proteins in the form of insoluble fibrils or plaques. The distinct molecular processes that...

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Autores principales: Aufschnaiter, Andreas, Kohler, Verena, Diessl, Jutta, Peselj, Carlotta, Carmona-Gutierrez, Didac, Keller, Walter, Büttner, Sabrina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5203858/
https://www.ncbi.nlm.nih.gov/pubmed/27449929
http://dx.doi.org/10.1007/s00441-016-2463-1
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author Aufschnaiter, Andreas
Kohler, Verena
Diessl, Jutta
Peselj, Carlotta
Carmona-Gutierrez, Didac
Keller, Walter
Büttner, Sabrina
author_facet Aufschnaiter, Andreas
Kohler, Verena
Diessl, Jutta
Peselj, Carlotta
Carmona-Gutierrez, Didac
Keller, Walter
Büttner, Sabrina
author_sort Aufschnaiter, Andreas
collection PubMed
description Mitochondrial dysfunction is a common feature of many neurodegenerative diseases, including proteinopathies such as Alzheimer’s or Parkinson’s disease, which are characterized by the deposition of aggregated proteins in the form of insoluble fibrils or plaques. The distinct molecular processes that eventually result in mitochondrial dysfunction during neurodegeneration are well studied but still not fully understood. However, defects in mitochondrial fission and fusion, mitophagy, oxidative phosphorylation and mitochondrial bioenergetics have been linked to cellular demise. These processes are influenced by the lipid environment within mitochondrial membranes as, besides membrane structure and curvature, recruitment and activity of different proteins also largely depend on the respective lipid composition. Hence, the interaction of neurotoxic proteins with certain lipids and the modification of lipid composition in different cell compartments, in particular mitochondria, decisively impact cell death associated with neurodegeneration. Here, we discuss the relevance of mitochondrial lipids in the pathological alterations that result in neuronal demise, focussing on proteinopathies.
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spelling pubmed-52038582017-01-13 Mitochondrial lipids in neurodegeneration Aufschnaiter, Andreas Kohler, Verena Diessl, Jutta Peselj, Carlotta Carmona-Gutierrez, Didac Keller, Walter Büttner, Sabrina Cell Tissue Res Review Mitochondrial dysfunction is a common feature of many neurodegenerative diseases, including proteinopathies such as Alzheimer’s or Parkinson’s disease, which are characterized by the deposition of aggregated proteins in the form of insoluble fibrils or plaques. The distinct molecular processes that eventually result in mitochondrial dysfunction during neurodegeneration are well studied but still not fully understood. However, defects in mitochondrial fission and fusion, mitophagy, oxidative phosphorylation and mitochondrial bioenergetics have been linked to cellular demise. These processes are influenced by the lipid environment within mitochondrial membranes as, besides membrane structure and curvature, recruitment and activity of different proteins also largely depend on the respective lipid composition. Hence, the interaction of neurotoxic proteins with certain lipids and the modification of lipid composition in different cell compartments, in particular mitochondria, decisively impact cell death associated with neurodegeneration. Here, we discuss the relevance of mitochondrial lipids in the pathological alterations that result in neuronal demise, focussing on proteinopathies. Springer Berlin Heidelberg 2016-07-23 2017 /pmc/articles/PMC5203858/ /pubmed/27449929 http://dx.doi.org/10.1007/s00441-016-2463-1 Text en © The Author(s) 2016 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Review
Aufschnaiter, Andreas
Kohler, Verena
Diessl, Jutta
Peselj, Carlotta
Carmona-Gutierrez, Didac
Keller, Walter
Büttner, Sabrina
Mitochondrial lipids in neurodegeneration
title Mitochondrial lipids in neurodegeneration
title_full Mitochondrial lipids in neurodegeneration
title_fullStr Mitochondrial lipids in neurodegeneration
title_full_unstemmed Mitochondrial lipids in neurodegeneration
title_short Mitochondrial lipids in neurodegeneration
title_sort mitochondrial lipids in neurodegeneration
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5203858/
https://www.ncbi.nlm.nih.gov/pubmed/27449929
http://dx.doi.org/10.1007/s00441-016-2463-1
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