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Correlation of Serum Cystatin C with Glomerular Filtration Rate in Patients Receiving Platinum-Based Chemotherapy
Objectives. Serum cystatin C seems to be an accurate marker of glomerular filtration rate (GFR) compared to serum creatinine. The aim of this work was to explore the possibility of using serum cystatin C instead of serum creatinine to early predict renal failure in cancer patients who received plati...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5203881/ https://www.ncbi.nlm.nih.gov/pubmed/28078200 http://dx.doi.org/10.1155/2016/4918325 |
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author | Cavalcanti, Ernesta Barchiesi, Vittoria Cerasuolo, Dionigio Di Paola, Flaviano Cantile, Monica Cecere, Sabrina Chiara Pignata, Sandro Morabito, Alessandro Costanzo, Raffaele Di Maio, Massimo Perrone, Francesco |
author_facet | Cavalcanti, Ernesta Barchiesi, Vittoria Cerasuolo, Dionigio Di Paola, Flaviano Cantile, Monica Cecere, Sabrina Chiara Pignata, Sandro Morabito, Alessandro Costanzo, Raffaele Di Maio, Massimo Perrone, Francesco |
author_sort | Cavalcanti, Ernesta |
collection | PubMed |
description | Objectives. Serum cystatin C seems to be an accurate marker of glomerular filtration rate (GFR) compared to serum creatinine. The aim of this work was to explore the possibility of using serum cystatin C instead of serum creatinine to early predict renal failure in cancer patients who received platinum based chemotherapy. Design and Methods. Serum creatinine, serum cystatin C concentrations, and GFR were determined simultaneously in 52 cancer patients received carboplatin-based or cisplatin-based chemotherapy. Serum creatinine was assayed on Cobas C6000-Roche, serum cystatin C assay was performed on AIA 360-Tosoh, and GFR was determined in all patients, before the first cycle of chemotherapy and before the subsequent administrations. Results. In the overall series, for the prediction of a fall of GFR < 80 mL/min/1.73 m(2), the AUC of the ROC curve for cystatin C was 0,667 and the best threshold was 1.135 mg/L (sensitivity 90.5%, specificity 61.1%). For a GFR fall < 60 mL/min/1.73 m(2), the AUC of ROC curve for cystatin C was 74.3% and the best threshold was 1.415 mg/L (sensitivity 66.7%, specificity 73.2%). Conclusions. Baseline cystatin C values were not able to predict renal failure during subsequent treatment. In conclusion, serum cystatin C is not a reliable early marker to efficiently predict renal failure in patients receiving chemotherapy. |
format | Online Article Text |
id | pubmed-5203881 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-52038812017-01-11 Correlation of Serum Cystatin C with Glomerular Filtration Rate in Patients Receiving Platinum-Based Chemotherapy Cavalcanti, Ernesta Barchiesi, Vittoria Cerasuolo, Dionigio Di Paola, Flaviano Cantile, Monica Cecere, Sabrina Chiara Pignata, Sandro Morabito, Alessandro Costanzo, Raffaele Di Maio, Massimo Perrone, Francesco Anal Cell Pathol (Amst) Research Article Objectives. Serum cystatin C seems to be an accurate marker of glomerular filtration rate (GFR) compared to serum creatinine. The aim of this work was to explore the possibility of using serum cystatin C instead of serum creatinine to early predict renal failure in cancer patients who received platinum based chemotherapy. Design and Methods. Serum creatinine, serum cystatin C concentrations, and GFR were determined simultaneously in 52 cancer patients received carboplatin-based or cisplatin-based chemotherapy. Serum creatinine was assayed on Cobas C6000-Roche, serum cystatin C assay was performed on AIA 360-Tosoh, and GFR was determined in all patients, before the first cycle of chemotherapy and before the subsequent administrations. Results. In the overall series, for the prediction of a fall of GFR < 80 mL/min/1.73 m(2), the AUC of the ROC curve for cystatin C was 0,667 and the best threshold was 1.135 mg/L (sensitivity 90.5%, specificity 61.1%). For a GFR fall < 60 mL/min/1.73 m(2), the AUC of ROC curve for cystatin C was 74.3% and the best threshold was 1.415 mg/L (sensitivity 66.7%, specificity 73.2%). Conclusions. Baseline cystatin C values were not able to predict renal failure during subsequent treatment. In conclusion, serum cystatin C is not a reliable early marker to efficiently predict renal failure in patients receiving chemotherapy. Hindawi Publishing Corporation 2016 2016-12-18 /pmc/articles/PMC5203881/ /pubmed/28078200 http://dx.doi.org/10.1155/2016/4918325 Text en Copyright © 2016 Ernesta Cavalcanti et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Cavalcanti, Ernesta Barchiesi, Vittoria Cerasuolo, Dionigio Di Paola, Flaviano Cantile, Monica Cecere, Sabrina Chiara Pignata, Sandro Morabito, Alessandro Costanzo, Raffaele Di Maio, Massimo Perrone, Francesco Correlation of Serum Cystatin C with Glomerular Filtration Rate in Patients Receiving Platinum-Based Chemotherapy |
title | Correlation of Serum Cystatin C with Glomerular Filtration Rate in Patients Receiving Platinum-Based Chemotherapy |
title_full | Correlation of Serum Cystatin C with Glomerular Filtration Rate in Patients Receiving Platinum-Based Chemotherapy |
title_fullStr | Correlation of Serum Cystatin C with Glomerular Filtration Rate in Patients Receiving Platinum-Based Chemotherapy |
title_full_unstemmed | Correlation of Serum Cystatin C with Glomerular Filtration Rate in Patients Receiving Platinum-Based Chemotherapy |
title_short | Correlation of Serum Cystatin C with Glomerular Filtration Rate in Patients Receiving Platinum-Based Chemotherapy |
title_sort | correlation of serum cystatin c with glomerular filtration rate in patients receiving platinum-based chemotherapy |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5203881/ https://www.ncbi.nlm.nih.gov/pubmed/28078200 http://dx.doi.org/10.1155/2016/4918325 |
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