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PPARδ as a Metabolic Initiator of Mammary Neoplasia and Immune Tolerance
PPARδ is a ligand-activated nuclear receptor that regulates the transcription of genes associated with proliferation, metabolism, inflammation, and immunity. Within this transcription factor family, PPARδ is unique in that it initiates oncogenesis in a metabolic and tissue-specific context, especial...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Hindawi Publishing Corporation
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5203902/ https://www.ncbi.nlm.nih.gov/pubmed/28077942 http://dx.doi.org/10.1155/2016/3082340 |
| _version_ | 1782489813943844864 |
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| author | Glazer, Robert I. |
| author_facet | Glazer, Robert I. |
| author_sort | Glazer, Robert I. |
| collection | PubMed |
| description | PPARδ is a ligand-activated nuclear receptor that regulates the transcription of genes associated with proliferation, metabolism, inflammation, and immunity. Within this transcription factor family, PPARδ is unique in that it initiates oncogenesis in a metabolic and tissue-specific context, especially in mammary epithelium, and can regulate autoimmunity in some tissues. This review discusses its role in these processes and how it ultimately impacts breast cancer. |
| format | Online Article Text |
| id | pubmed-5203902 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2016 |
| publisher | Hindawi Publishing Corporation |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-52039022017-01-11 PPARδ as a Metabolic Initiator of Mammary Neoplasia and Immune Tolerance Glazer, Robert I. PPAR Res Review Article PPARδ is a ligand-activated nuclear receptor that regulates the transcription of genes associated with proliferation, metabolism, inflammation, and immunity. Within this transcription factor family, PPARδ is unique in that it initiates oncogenesis in a metabolic and tissue-specific context, especially in mammary epithelium, and can regulate autoimmunity in some tissues. This review discusses its role in these processes and how it ultimately impacts breast cancer. Hindawi Publishing Corporation 2016 2016-12-18 /pmc/articles/PMC5203902/ /pubmed/28077942 http://dx.doi.org/10.1155/2016/3082340 Text en Copyright © 2016 Robert I. Glazer. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| spellingShingle | Review Article Glazer, Robert I. PPARδ as a Metabolic Initiator of Mammary Neoplasia and Immune Tolerance |
| title | PPARδ as a Metabolic Initiator of Mammary Neoplasia and Immune Tolerance |
| title_full | PPARδ as a Metabolic Initiator of Mammary Neoplasia and Immune Tolerance |
| title_fullStr | PPARδ as a Metabolic Initiator of Mammary Neoplasia and Immune Tolerance |
| title_full_unstemmed | PPARδ as a Metabolic Initiator of Mammary Neoplasia and Immune Tolerance |
| title_short | PPARδ as a Metabolic Initiator of Mammary Neoplasia and Immune Tolerance |
| title_sort | pparδ as a metabolic initiator of mammary neoplasia and immune tolerance |
| topic | Review Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5203902/ https://www.ncbi.nlm.nih.gov/pubmed/28077942 http://dx.doi.org/10.1155/2016/3082340 |
| work_keys_str_mv | AT glazerroberti ppardasametabolicinitiatorofmammaryneoplasiaandimmunetolerance |