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Nitrative and oxidative DNA damage in infection-related carcinogenesis in relation to cancer stem cells

Infection and chronic inflammation have been recognized as important factors for carcinogenesis. Under inflammatory conditions, reactive oxygen species (ROS) and reactive nitrogen species (RNS) are generated from inflammatory and epithelial cells, and result in the formation of oxidative and nitrati...

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Autores principales: Kawanishi, Shosuke, Ohnishi, Shiho, Ma, Ning, Hiraku, Yusuke, Oikawa, Shinji, Murata, Mariko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5203929/
https://www.ncbi.nlm.nih.gov/pubmed/28050219
http://dx.doi.org/10.1186/s41021-016-0055-7
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author Kawanishi, Shosuke
Ohnishi, Shiho
Ma, Ning
Hiraku, Yusuke
Oikawa, Shinji
Murata, Mariko
author_facet Kawanishi, Shosuke
Ohnishi, Shiho
Ma, Ning
Hiraku, Yusuke
Oikawa, Shinji
Murata, Mariko
author_sort Kawanishi, Shosuke
collection PubMed
description Infection and chronic inflammation have been recognized as important factors for carcinogenesis. Under inflammatory conditions, reactive oxygen species (ROS) and reactive nitrogen species (RNS) are generated from inflammatory and epithelial cells, and result in the formation of oxidative and nitrative DNA lesions, such as 8-oxo-7,8-dihydro-2’-deoxyguanosine (8-oxodG) and 8-nitroguanine. The DNA damage can cause mutations and has been implicated in inflammation-mediated carcinogenesis. It has been estimated that various infectious agents are carcinogenic to humans (IARC group 1), including bacterium Helicobacter pylori (H. pylori), viruses [hepatitis B virus (HBV), hepatitis C virus (HCV), human papillomavirus (HPV) and Epstein-Barr virus (EBV)] and parasites [Schistosoma haematobium (SH) and Opisthorchis viverrini (OV)]. H. pylori, HBV/HCV, HPV, EBV, SH and OV are important risk factors for gastric cancer, hepatocellular carcinoma, nasopharyngeal carcinoma, bladder cancer, and cholangiocarcinoma, respectively. We demonstrated that 8-nitroguanine was strongly formed via inducible nitric oxide synthase (iNOS) expression at these cancer sites of patients. Moreover, 8-nitroguanine was formed in Oct3/4-positive stem cells in SH-associated bladder cancer tissues, and in Oct3/4- and CD133-positive stem cells in OV-associated cholangiocarcinoma tissues. Therefore, it is considered that nitrative and oxidative DNA damage in stem cells may play a key role in infection-related carcinogenesis via chronic inflammation.
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spelling pubmed-52039292017-01-03 Nitrative and oxidative DNA damage in infection-related carcinogenesis in relation to cancer stem cells Kawanishi, Shosuke Ohnishi, Shiho Ma, Ning Hiraku, Yusuke Oikawa, Shinji Murata, Mariko Genes Environ Review Infection and chronic inflammation have been recognized as important factors for carcinogenesis. Under inflammatory conditions, reactive oxygen species (ROS) and reactive nitrogen species (RNS) are generated from inflammatory and epithelial cells, and result in the formation of oxidative and nitrative DNA lesions, such as 8-oxo-7,8-dihydro-2’-deoxyguanosine (8-oxodG) and 8-nitroguanine. The DNA damage can cause mutations and has been implicated in inflammation-mediated carcinogenesis. It has been estimated that various infectious agents are carcinogenic to humans (IARC group 1), including bacterium Helicobacter pylori (H. pylori), viruses [hepatitis B virus (HBV), hepatitis C virus (HCV), human papillomavirus (HPV) and Epstein-Barr virus (EBV)] and parasites [Schistosoma haematobium (SH) and Opisthorchis viverrini (OV)]. H. pylori, HBV/HCV, HPV, EBV, SH and OV are important risk factors for gastric cancer, hepatocellular carcinoma, nasopharyngeal carcinoma, bladder cancer, and cholangiocarcinoma, respectively. We demonstrated that 8-nitroguanine was strongly formed via inducible nitric oxide synthase (iNOS) expression at these cancer sites of patients. Moreover, 8-nitroguanine was formed in Oct3/4-positive stem cells in SH-associated bladder cancer tissues, and in Oct3/4- and CD133-positive stem cells in OV-associated cholangiocarcinoma tissues. Therefore, it is considered that nitrative and oxidative DNA damage in stem cells may play a key role in infection-related carcinogenesis via chronic inflammation. BioMed Central 2017-01-01 /pmc/articles/PMC5203929/ /pubmed/28050219 http://dx.doi.org/10.1186/s41021-016-0055-7 Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Kawanishi, Shosuke
Ohnishi, Shiho
Ma, Ning
Hiraku, Yusuke
Oikawa, Shinji
Murata, Mariko
Nitrative and oxidative DNA damage in infection-related carcinogenesis in relation to cancer stem cells
title Nitrative and oxidative DNA damage in infection-related carcinogenesis in relation to cancer stem cells
title_full Nitrative and oxidative DNA damage in infection-related carcinogenesis in relation to cancer stem cells
title_fullStr Nitrative and oxidative DNA damage in infection-related carcinogenesis in relation to cancer stem cells
title_full_unstemmed Nitrative and oxidative DNA damage in infection-related carcinogenesis in relation to cancer stem cells
title_short Nitrative and oxidative DNA damage in infection-related carcinogenesis in relation to cancer stem cells
title_sort nitrative and oxidative dna damage in infection-related carcinogenesis in relation to cancer stem cells
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5203929/
https://www.ncbi.nlm.nih.gov/pubmed/28050219
http://dx.doi.org/10.1186/s41021-016-0055-7
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