Cargando…

A Case of Transverse Myelitis Caused by Varicella Zoster Virus in an Immunocompetent Older Patient

Varicella zoster virus (VZV) is a human neurotropic alphaherpesvirus that causes chickenpox (varicella) in children. VZV reactivation may lead to neurological complications, including transverse myelitis. However, transverse myelitis caused by VZV reactivation is rare in immunocompetent patients. He...

Descripción completa

Detalles Bibliográficos
Autores principales: Lee, Jeong Eun, Lee, Shinwon, Kim, Kye-Hyung, Jang, Hee Ryeong, Park, Young Joo, Kang, Jin Suk, Han, Sung Yong, Lee, Sun Hee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Infectious Diseases and Korean Society for Chemotherapy 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5204014/
https://www.ncbi.nlm.nih.gov/pubmed/27883372
http://dx.doi.org/10.3947/ic.2016.48.4.334
_version_ 1782489825839939584
author Lee, Jeong Eun
Lee, Shinwon
Kim, Kye-Hyung
Jang, Hee Ryeong
Park, Young Joo
Kang, Jin Suk
Han, Sung Yong
Lee, Sun Hee
author_facet Lee, Jeong Eun
Lee, Shinwon
Kim, Kye-Hyung
Jang, Hee Ryeong
Park, Young Joo
Kang, Jin Suk
Han, Sung Yong
Lee, Sun Hee
author_sort Lee, Jeong Eun
collection PubMed
description Varicella zoster virus (VZV) is a human neurotropic alphaherpesvirus that causes chickenpox (varicella) in children. VZV reactivation may lead to neurological complications, including transverse myelitis. However, transverse myelitis caused by VZV reactivation is rare in immunocompetent patients. Herein, we report a case of transverse myelitis caused by VZV in an immunocompetent older patient, and confirmed this case by polymerase chain reaction. A 79-year-old woman visited our service with complaints of weakness in the right lower leg, generalized vesicular eruptions, and throbbing pain in the right flank for ten days. Spine MRI showed transverse myelitis in the thoracic spine at level T4–T11. The patient was treated with acyclovir and her neurological functions improved, except for sensory impairment below level T10. For older patients, early and aggressive antiviral treatment against VZV may be necessary even though these patients are immunocompetent.
format Online
Article
Text
id pubmed-5204014
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher The Korean Society of Infectious Diseases and Korean Society for Chemotherapy
record_format MEDLINE/PubMed
spelling pubmed-52040142017-01-04 A Case of Transverse Myelitis Caused by Varicella Zoster Virus in an Immunocompetent Older Patient Lee, Jeong Eun Lee, Shinwon Kim, Kye-Hyung Jang, Hee Ryeong Park, Young Joo Kang, Jin Suk Han, Sung Yong Lee, Sun Hee Infect Chemother Case Report Varicella zoster virus (VZV) is a human neurotropic alphaherpesvirus that causes chickenpox (varicella) in children. VZV reactivation may lead to neurological complications, including transverse myelitis. However, transverse myelitis caused by VZV reactivation is rare in immunocompetent patients. Herein, we report a case of transverse myelitis caused by VZV in an immunocompetent older patient, and confirmed this case by polymerase chain reaction. A 79-year-old woman visited our service with complaints of weakness in the right lower leg, generalized vesicular eruptions, and throbbing pain in the right flank for ten days. Spine MRI showed transverse myelitis in the thoracic spine at level T4–T11. The patient was treated with acyclovir and her neurological functions improved, except for sensory impairment below level T10. For older patients, early and aggressive antiviral treatment against VZV may be necessary even though these patients are immunocompetent. The Korean Society of Infectious Diseases and Korean Society for Chemotherapy 2016-12 2016-11-11 /pmc/articles/PMC5204014/ /pubmed/27883372 http://dx.doi.org/10.3947/ic.2016.48.4.334 Text en Copyright © 2016 by The Korean Society of Infectious Diseases and Korean Society for Chemotherapy http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Lee, Jeong Eun
Lee, Shinwon
Kim, Kye-Hyung
Jang, Hee Ryeong
Park, Young Joo
Kang, Jin Suk
Han, Sung Yong
Lee, Sun Hee
A Case of Transverse Myelitis Caused by Varicella Zoster Virus in an Immunocompetent Older Patient
title A Case of Transverse Myelitis Caused by Varicella Zoster Virus in an Immunocompetent Older Patient
title_full A Case of Transverse Myelitis Caused by Varicella Zoster Virus in an Immunocompetent Older Patient
title_fullStr A Case of Transverse Myelitis Caused by Varicella Zoster Virus in an Immunocompetent Older Patient
title_full_unstemmed A Case of Transverse Myelitis Caused by Varicella Zoster Virus in an Immunocompetent Older Patient
title_short A Case of Transverse Myelitis Caused by Varicella Zoster Virus in an Immunocompetent Older Patient
title_sort case of transverse myelitis caused by varicella zoster virus in an immunocompetent older patient
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5204014/
https://www.ncbi.nlm.nih.gov/pubmed/27883372
http://dx.doi.org/10.3947/ic.2016.48.4.334
work_keys_str_mv AT leejeongeun acaseoftransversemyelitiscausedbyvaricellazostervirusinanimmunocompetentolderpatient
AT leeshinwon acaseoftransversemyelitiscausedbyvaricellazostervirusinanimmunocompetentolderpatient
AT kimkyehyung acaseoftransversemyelitiscausedbyvaricellazostervirusinanimmunocompetentolderpatient
AT jangheeryeong acaseoftransversemyelitiscausedbyvaricellazostervirusinanimmunocompetentolderpatient
AT parkyoungjoo acaseoftransversemyelitiscausedbyvaricellazostervirusinanimmunocompetentolderpatient
AT kangjinsuk acaseoftransversemyelitiscausedbyvaricellazostervirusinanimmunocompetentolderpatient
AT hansungyong acaseoftransversemyelitiscausedbyvaricellazostervirusinanimmunocompetentolderpatient
AT leesunhee acaseoftransversemyelitiscausedbyvaricellazostervirusinanimmunocompetentolderpatient
AT leejeongeun caseoftransversemyelitiscausedbyvaricellazostervirusinanimmunocompetentolderpatient
AT leeshinwon caseoftransversemyelitiscausedbyvaricellazostervirusinanimmunocompetentolderpatient
AT kimkyehyung caseoftransversemyelitiscausedbyvaricellazostervirusinanimmunocompetentolderpatient
AT jangheeryeong caseoftransversemyelitiscausedbyvaricellazostervirusinanimmunocompetentolderpatient
AT parkyoungjoo caseoftransversemyelitiscausedbyvaricellazostervirusinanimmunocompetentolderpatient
AT kangjinsuk caseoftransversemyelitiscausedbyvaricellazostervirusinanimmunocompetentolderpatient
AT hansungyong caseoftransversemyelitiscausedbyvaricellazostervirusinanimmunocompetentolderpatient
AT leesunhee caseoftransversemyelitiscausedbyvaricellazostervirusinanimmunocompetentolderpatient