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Prognostic Factors and a New Prognostic Index Model for Children and Adolescents with Hodgkin’s Lymphoma Who Underwent Autologous Hematopoietic Stem Cell Transplantation: A Multicenter Study of the Turkish Pediatric Bone Marrow Transplantation Study Group
OBJECTIVE: The prognostic factors and a new childhood prognostic index after autologous hematopoietic stem cell transplantation (AHSCT) in patients with relapsed/refractory Hodgkin’s lymphoma (HL) were evaluated. MATERIALS AND METHODS: The prognostic factors of 61 patients who underwent AHSCT betwee...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Galenos Publishing
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5204179/ https://www.ncbi.nlm.nih.gov/pubmed/27094103 http://dx.doi.org/10.4274/tjh.2015.0280 |
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author | Kesik, Vural Ataş, Erman Karakükcü, Musa Aksoylar, Serap Erbey, Fatih Taçyıldız, Nurdan Küpesiz, Alphan Öniz, Haldun Ünal, Ekrem Kansoy, Savaş Öztürk, Gülyüz Elli, Murat Kaya, Zühre Ünal, Emel Hazar, Volkan Yılmaz Bengoa, Şebnem Karasu, Gülsün Atay, Didem Dağdemir, Ayhan Ören, Hale Koçak, Ülker Yeşilipek, M. Akif |
author_facet | Kesik, Vural Ataş, Erman Karakükcü, Musa Aksoylar, Serap Erbey, Fatih Taçyıldız, Nurdan Küpesiz, Alphan Öniz, Haldun Ünal, Ekrem Kansoy, Savaş Öztürk, Gülyüz Elli, Murat Kaya, Zühre Ünal, Emel Hazar, Volkan Yılmaz Bengoa, Şebnem Karasu, Gülsün Atay, Didem Dağdemir, Ayhan Ören, Hale Koçak, Ülker Yeşilipek, M. Akif |
author_sort | Kesik, Vural |
collection | PubMed |
description | OBJECTIVE: The prognostic factors and a new childhood prognostic index after autologous hematopoietic stem cell transplantation (AHSCT) in patients with relapsed/refractory Hodgkin’s lymphoma (HL) were evaluated. MATERIALS AND METHODS: The prognostic factors of 61 patients who underwent AHSCT between January 1990 and December 2014 were evaluated. In addition, the Age-Adjusted International Prognostic Index and the Childhood International Prognostic Index (CIPI) were evaluated for their impact on prognosis. RESULTS: The median age of the 61 patients was 14.8 years (minimum-maximum: 5-20 years) at the time of AHSCT. There were single relapses in 28 patients, ≥2 relapses in eight patients, and refractory disease in 25 patients. The chemosensitivity/chemorefractory ratio was 36/25. No pretransplant radiotherapy, no remission at the time of transplantation, posttransplant white blood cell count over 10x10(3)/µL, posttransplant positron emission tomography positivity at day 100, and serum albumin of <2.5 g/dL at diagnosis were correlated with progression-free survival. No remission at the time of transplantation, bone marrow positivity at diagnosis, and relapse after AHSCT were significant parameters for overall survival. CONCLUSION: The major factors affecting the progression-free and overall survival were clearly demonstrated. A CIPI that uses a lactate dehydrogenase level of 500 IU/L worked well for estimating the prognosis. We recommend AHSCT at first complete remission for relapsed cases, and it should also be taken into consideration for patients with high prognostic scores at diagnosis. |
format | Online Article Text |
id | pubmed-5204179 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Galenos Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-52041792017-01-06 Prognostic Factors and a New Prognostic Index Model for Children and Adolescents with Hodgkin’s Lymphoma Who Underwent Autologous Hematopoietic Stem Cell Transplantation: A Multicenter Study of the Turkish Pediatric Bone Marrow Transplantation Study Group Kesik, Vural Ataş, Erman Karakükcü, Musa Aksoylar, Serap Erbey, Fatih Taçyıldız, Nurdan Küpesiz, Alphan Öniz, Haldun Ünal, Ekrem Kansoy, Savaş Öztürk, Gülyüz Elli, Murat Kaya, Zühre Ünal, Emel Hazar, Volkan Yılmaz Bengoa, Şebnem Karasu, Gülsün Atay, Didem Dağdemir, Ayhan Ören, Hale Koçak, Ülker Yeşilipek, M. Akif Turk J Haematol Research Article OBJECTIVE: The prognostic factors and a new childhood prognostic index after autologous hematopoietic stem cell transplantation (AHSCT) in patients with relapsed/refractory Hodgkin’s lymphoma (HL) were evaluated. MATERIALS AND METHODS: The prognostic factors of 61 patients who underwent AHSCT between January 1990 and December 2014 were evaluated. In addition, the Age-Adjusted International Prognostic Index and the Childhood International Prognostic Index (CIPI) were evaluated for their impact on prognosis. RESULTS: The median age of the 61 patients was 14.8 years (minimum-maximum: 5-20 years) at the time of AHSCT. There were single relapses in 28 patients, ≥2 relapses in eight patients, and refractory disease in 25 patients. The chemosensitivity/chemorefractory ratio was 36/25. No pretransplant radiotherapy, no remission at the time of transplantation, posttransplant white blood cell count over 10x10(3)/µL, posttransplant positron emission tomography positivity at day 100, and serum albumin of <2.5 g/dL at diagnosis were correlated with progression-free survival. No remission at the time of transplantation, bone marrow positivity at diagnosis, and relapse after AHSCT were significant parameters for overall survival. CONCLUSION: The major factors affecting the progression-free and overall survival were clearly demonstrated. A CIPI that uses a lactate dehydrogenase level of 500 IU/L worked well for estimating the prognosis. We recommend AHSCT at first complete remission for relapsed cases, and it should also be taken into consideration for patients with high prognostic scores at diagnosis. Galenos Publishing 2016-12 2016-12-01 /pmc/articles/PMC5204179/ /pubmed/27094103 http://dx.doi.org/10.4274/tjh.2015.0280 Text en © Turkish Journal of Hematology, Published by Galenos Publishing. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Kesik, Vural Ataş, Erman Karakükcü, Musa Aksoylar, Serap Erbey, Fatih Taçyıldız, Nurdan Küpesiz, Alphan Öniz, Haldun Ünal, Ekrem Kansoy, Savaş Öztürk, Gülyüz Elli, Murat Kaya, Zühre Ünal, Emel Hazar, Volkan Yılmaz Bengoa, Şebnem Karasu, Gülsün Atay, Didem Dağdemir, Ayhan Ören, Hale Koçak, Ülker Yeşilipek, M. Akif Prognostic Factors and a New Prognostic Index Model for Children and Adolescents with Hodgkin’s Lymphoma Who Underwent Autologous Hematopoietic Stem Cell Transplantation: A Multicenter Study of the Turkish Pediatric Bone Marrow Transplantation Study Group |
title | Prognostic Factors and a New Prognostic Index Model for Children and Adolescents with Hodgkin’s Lymphoma Who Underwent Autologous Hematopoietic Stem Cell Transplantation: A Multicenter Study of the Turkish Pediatric Bone Marrow Transplantation Study Group |
title_full | Prognostic Factors and a New Prognostic Index Model for Children and Adolescents with Hodgkin’s Lymphoma Who Underwent Autologous Hematopoietic Stem Cell Transplantation: A Multicenter Study of the Turkish Pediatric Bone Marrow Transplantation Study Group |
title_fullStr | Prognostic Factors and a New Prognostic Index Model for Children and Adolescents with Hodgkin’s Lymphoma Who Underwent Autologous Hematopoietic Stem Cell Transplantation: A Multicenter Study of the Turkish Pediatric Bone Marrow Transplantation Study Group |
title_full_unstemmed | Prognostic Factors and a New Prognostic Index Model for Children and Adolescents with Hodgkin’s Lymphoma Who Underwent Autologous Hematopoietic Stem Cell Transplantation: A Multicenter Study of the Turkish Pediatric Bone Marrow Transplantation Study Group |
title_short | Prognostic Factors and a New Prognostic Index Model for Children and Adolescents with Hodgkin’s Lymphoma Who Underwent Autologous Hematopoietic Stem Cell Transplantation: A Multicenter Study of the Turkish Pediatric Bone Marrow Transplantation Study Group |
title_sort | prognostic factors and a new prognostic index model for children and adolescents with hodgkin’s lymphoma who underwent autologous hematopoietic stem cell transplantation: a multicenter study of the turkish pediatric bone marrow transplantation study group |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5204179/ https://www.ncbi.nlm.nih.gov/pubmed/27094103 http://dx.doi.org/10.4274/tjh.2015.0280 |
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