Clinical Courses of Two Pediatric Patients with Acute Megakaryoblastic Leukemia Harboring the CBFA2T3-GLIS2 Fusion Gene

Acute megakaryoblastic leukemia (AMKL) in children without Down syndrome (DS) has an extremely poor outcome with 3-year survival of less than 40%, whereas AMKL in children with DS has an excellent survival rate. Recently, a novel recurrent translocation involving CBFA2T3 and GLIS2 was identified in...

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Autores principales: Ishibashi, Mayu, Yokosuka, Tomoko, Yanagimachi, Masakatsu D., Iwasaki, Fuminori, Tsujimoto, Shin-ichi, Sasaki, Koji, Takeuchi, Masanobu, Tanoshima, Reo, Kato, Hiromi, Kajiwara, Ryosuke, Tanaka, Fumiko, Goto, Hiroaki, Yokota, Shumpei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Galenos Publishing 2016
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5204189/
https://www.ncbi.nlm.nih.gov/pubmed/27094503
http://dx.doi.org/10.4274/tjh.2016.0008
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author Ishibashi, Mayu
Yokosuka, Tomoko
Yanagimachi, Masakatsu D.
Iwasaki, Fuminori
Tsujimoto, Shin-ichi
Sasaki, Koji
Takeuchi, Masanobu
Tanoshima, Reo
Kato, Hiromi
Kajiwara, Ryosuke
Tanaka, Fumiko
Goto, Hiroaki
Yokota, Shumpei
author_facet Ishibashi, Mayu
Yokosuka, Tomoko
Yanagimachi, Masakatsu D.
Iwasaki, Fuminori
Tsujimoto, Shin-ichi
Sasaki, Koji
Takeuchi, Masanobu
Tanoshima, Reo
Kato, Hiromi
Kajiwara, Ryosuke
Tanaka, Fumiko
Goto, Hiroaki
Yokota, Shumpei
author_sort Ishibashi, Mayu
collection PubMed
description Acute megakaryoblastic leukemia (AMKL) in children without Down syndrome (DS) has an extremely poor outcome with 3-year survival of less than 40%, whereas AMKL in children with DS has an excellent survival rate. Recently, a novel recurrent translocation involving CBFA2T3 and GLIS2 was identified in about 30% of children with non-DS AMKL, and the fusion gene was reported as a strong poor prognostic factor in pediatric AMKL. We report the difficult clinical courses of pediatric patients with AMKL harboring the CBFA2T3-GLIS2 fusion gene.
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spelling pubmed-52041892017-01-06 Clinical Courses of Two Pediatric Patients with Acute Megakaryoblastic Leukemia Harboring the CBFA2T3-GLIS2 Fusion Gene Ishibashi, Mayu Yokosuka, Tomoko Yanagimachi, Masakatsu D. Iwasaki, Fuminori Tsujimoto, Shin-ichi Sasaki, Koji Takeuchi, Masanobu Tanoshima, Reo Kato, Hiromi Kajiwara, Ryosuke Tanaka, Fumiko Goto, Hiroaki Yokota, Shumpei Turk J Haematol Brief Report Acute megakaryoblastic leukemia (AMKL) in children without Down syndrome (DS) has an extremely poor outcome with 3-year survival of less than 40%, whereas AMKL in children with DS has an excellent survival rate. Recently, a novel recurrent translocation involving CBFA2T3 and GLIS2 was identified in about 30% of children with non-DS AMKL, and the fusion gene was reported as a strong poor prognostic factor in pediatric AMKL. We report the difficult clinical courses of pediatric patients with AMKL harboring the CBFA2T3-GLIS2 fusion gene. Galenos Publishing 2016-12 2016-12-01 /pmc/articles/PMC5204189/ /pubmed/27094503 http://dx.doi.org/10.4274/tjh.2016.0008 Text en © Turkish Journal of Hematology, Published by Galenos Publishing. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Report
Ishibashi, Mayu
Yokosuka, Tomoko
Yanagimachi, Masakatsu D.
Iwasaki, Fuminori
Tsujimoto, Shin-ichi
Sasaki, Koji
Takeuchi, Masanobu
Tanoshima, Reo
Kato, Hiromi
Kajiwara, Ryosuke
Tanaka, Fumiko
Goto, Hiroaki
Yokota, Shumpei
Clinical Courses of Two Pediatric Patients with Acute Megakaryoblastic Leukemia Harboring the CBFA2T3-GLIS2 Fusion Gene
title Clinical Courses of Two Pediatric Patients with Acute Megakaryoblastic Leukemia Harboring the CBFA2T3-GLIS2 Fusion Gene
title_full Clinical Courses of Two Pediatric Patients with Acute Megakaryoblastic Leukemia Harboring the CBFA2T3-GLIS2 Fusion Gene
title_fullStr Clinical Courses of Two Pediatric Patients with Acute Megakaryoblastic Leukemia Harboring the CBFA2T3-GLIS2 Fusion Gene
title_full_unstemmed Clinical Courses of Two Pediatric Patients with Acute Megakaryoblastic Leukemia Harboring the CBFA2T3-GLIS2 Fusion Gene
title_short Clinical Courses of Two Pediatric Patients with Acute Megakaryoblastic Leukemia Harboring the CBFA2T3-GLIS2 Fusion Gene
title_sort clinical courses of two pediatric patients with acute megakaryoblastic leukemia harboring the cbfa2t3-glis2 fusion gene
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5204189/
https://www.ncbi.nlm.nih.gov/pubmed/27094503
http://dx.doi.org/10.4274/tjh.2016.0008
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