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Reconstructing genetic history of Siberian and Northeastern European populations
Siberia and Northwestern Russia are home to over 40 culturally and linguistically diverse indigenous ethnic groups, yet genetic variation and histories of peoples from this region are largely uncharacterized. We present deep whole-genome sequencing data (∼38×) from 28 individuals belonging to 14 dis...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory Press
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5204334/ https://www.ncbi.nlm.nih.gov/pubmed/27965293 http://dx.doi.org/10.1101/gr.202945.115 |
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author | Wong, Emily H.M. Khrunin, Andrey Nichols, Larissa Pushkarev, Dmitry Khokhrin, Denis Verbenko, Dmitry Evgrafov, Oleg Knowles, James Novembre, John Limborska, Svetlana Valouev, Anton |
author_facet | Wong, Emily H.M. Khrunin, Andrey Nichols, Larissa Pushkarev, Dmitry Khokhrin, Denis Verbenko, Dmitry Evgrafov, Oleg Knowles, James Novembre, John Limborska, Svetlana Valouev, Anton |
author_sort | Wong, Emily H.M. |
collection | PubMed |
description | Siberia and Northwestern Russia are home to over 40 culturally and linguistically diverse indigenous ethnic groups, yet genetic variation and histories of peoples from this region are largely uncharacterized. We present deep whole-genome sequencing data (∼38×) from 28 individuals belonging to 14 distinct indigenous populations from that region. We combined these data sets with additional 32 modern-day and 46 ancient human genomes to reconstruct genetic histories of several indigenous Northern Eurasian populations. We found that Siberian and East Asian populations shared 38% of their ancestry with a 45,000-yr-old Ust’-Ishim individual who was previously believed to have no modern-day descendants. Western Siberians trace 57% of their ancestry to ancient North Eurasians, represented by the 24,000-yr-old Siberian Mal'ta boy MA-1. Eastern Siberian populations formed a distinct sublineage that separated from other East Asian populations ∼10,000 yr ago. In addition, we uncovered admixtures between Siberians and Eastern European hunter-gatherers from Samara, Karelia, Hungary, and Sweden (from 8000–6600 yr ago); Yamnaya people (5300–4700 yr ago); and modern-day Northeastern Europeans. Our results provide new insights into genetic histories of Siberian and Northeastern European populations and evidence of ancient gene flow from Siberia into Europe. |
format | Online Article Text |
id | pubmed-5204334 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Cold Spring Harbor Laboratory Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-52043342017-07-01 Reconstructing genetic history of Siberian and Northeastern European populations Wong, Emily H.M. Khrunin, Andrey Nichols, Larissa Pushkarev, Dmitry Khokhrin, Denis Verbenko, Dmitry Evgrafov, Oleg Knowles, James Novembre, John Limborska, Svetlana Valouev, Anton Genome Res Research Siberia and Northwestern Russia are home to over 40 culturally and linguistically diverse indigenous ethnic groups, yet genetic variation and histories of peoples from this region are largely uncharacterized. We present deep whole-genome sequencing data (∼38×) from 28 individuals belonging to 14 distinct indigenous populations from that region. We combined these data sets with additional 32 modern-day and 46 ancient human genomes to reconstruct genetic histories of several indigenous Northern Eurasian populations. We found that Siberian and East Asian populations shared 38% of their ancestry with a 45,000-yr-old Ust’-Ishim individual who was previously believed to have no modern-day descendants. Western Siberians trace 57% of their ancestry to ancient North Eurasians, represented by the 24,000-yr-old Siberian Mal'ta boy MA-1. Eastern Siberian populations formed a distinct sublineage that separated from other East Asian populations ∼10,000 yr ago. In addition, we uncovered admixtures between Siberians and Eastern European hunter-gatherers from Samara, Karelia, Hungary, and Sweden (from 8000–6600 yr ago); Yamnaya people (5300–4700 yr ago); and modern-day Northeastern Europeans. Our results provide new insights into genetic histories of Siberian and Northeastern European populations and evidence of ancient gene flow from Siberia into Europe. Cold Spring Harbor Laboratory Press 2017-01 /pmc/articles/PMC5204334/ /pubmed/27965293 http://dx.doi.org/10.1101/gr.202945.115 Text en © 2017 Wong et al.; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genome.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/. |
spellingShingle | Research Wong, Emily H.M. Khrunin, Andrey Nichols, Larissa Pushkarev, Dmitry Khokhrin, Denis Verbenko, Dmitry Evgrafov, Oleg Knowles, James Novembre, John Limborska, Svetlana Valouev, Anton Reconstructing genetic history of Siberian and Northeastern European populations |
title | Reconstructing genetic history of Siberian and Northeastern European populations |
title_full | Reconstructing genetic history of Siberian and Northeastern European populations |
title_fullStr | Reconstructing genetic history of Siberian and Northeastern European populations |
title_full_unstemmed | Reconstructing genetic history of Siberian and Northeastern European populations |
title_short | Reconstructing genetic history of Siberian and Northeastern European populations |
title_sort | reconstructing genetic history of siberian and northeastern european populations |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5204334/ https://www.ncbi.nlm.nih.gov/pubmed/27965293 http://dx.doi.org/10.1101/gr.202945.115 |
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