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A phosphorylation–deubiquitination cascade regulates the BRCA2–RAD51 axis in homologous recombination
Homologous recombination (HR) is one of the major DNA double-strand break (DSB) repair pathways in mammalian cells. Defects in HR trigger genomic instability and result in cancer predisposition. The defining step of HR is homologous strand exchange directed by the protein RAD51, which is recruited t...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cold Spring Harbor Laboratory Press
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5204351/ https://www.ncbi.nlm.nih.gov/pubmed/27941124 http://dx.doi.org/10.1101/gad.289439.116 |