Overexpression of N141I PS2 increases γ-secretase activity through up-regulation of Presenilin and Pen-2 in brain mitochondria of NSE/hPS2m transgenic mice

Alzheimer's disease (AD) is known to induce alterations of mitochondrial function such as elevation of oxidative stress and activation of apopotosis. The aim of this study was to investigate the effects of human Presenilin 2 mutant (hPS2m) overexpression on the γ-secretase complex in the mitoch...

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Detalles Bibliográficos
Autores principales: Yun, Woo Bin, Park, Jin Ju, Kim, Ji Eun, Sung, Ji Eun, Lee, Hyun Ah, Lee, Jae Ho, Bae, Chang Jun, Hwang, Dae Youn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Association for Laboratory Animal Science 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5206232/
https://www.ncbi.nlm.nih.gov/pubmed/28053619
http://dx.doi.org/10.5625/lar.2016.32.4.249

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5206232/
https://www.ncbi.nlm.nih.gov/pubmed/28053619
http://dx.doi.org/10.5625/lar.2016.32.4.249

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