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Clinical and magnetic resonance imaging features of compressive cervical myelopathy with traumatic intervertebral disc herniation in cynomolgus macaque (Macaca fascicularis)

Intervertebral disc herniation (IVDH) with nucleus pulposus extrusion, traumatic or not, is a devastating clinical condition accompanied by neurological problems. Here we report a cynomolgus macaque suffering from acute and progressive neurological dysfunction by a blunt trauma due to neck collar, a...

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Autores principales: Choi, Yun-Jung, Park, Hye-Jin, Sohn, Chul-Ho, Jung, Kyeong Cheon, Park, Seong Hoe, Lee, Jae-Il
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Association for Laboratory Animal Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5206234/
https://www.ncbi.nlm.nih.gov/pubmed/28053621
http://dx.doi.org/10.5625/lar.2016.32.4.267
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author Choi, Yun-Jung
Park, Hye-Jin
Sohn, Chul-Ho
Jung, Kyeong Cheon
Park, Seong Hoe
Lee, Jae-Il
author_facet Choi, Yun-Jung
Park, Hye-Jin
Sohn, Chul-Ho
Jung, Kyeong Cheon
Park, Seong Hoe
Lee, Jae-Il
author_sort Choi, Yun-Jung
collection PubMed
description Intervertebral disc herniation (IVDH) with nucleus pulposus extrusion, traumatic or not, is a devastating clinical condition accompanied by neurological problems. Here we report a cynomolgus macaque suffering from acute and progressive neurological dysfunction by a blunt trauma due to neck collar, an animal handling device. Tetraplegia, urinary incontinence, decreased proprioception, and imperception of pain were shown on physical and neurological examinations. MRI sagittal T2 weighted sequences revealed an extensive protrusion of disc material between C2 and C3 cervical vertebra, and this protrusion resulted in central stenosis of the spinal cord. Histopathologic findings showed a large number of inflammatory cells infiltrated at sites of spinal cord injury (SCI). This case is the first report of compressive cervical SCI caused by IVDH associated with blunt trauma.
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spelling pubmed-52062342017-01-04 Clinical and magnetic resonance imaging features of compressive cervical myelopathy with traumatic intervertebral disc herniation in cynomolgus macaque (Macaca fascicularis) Choi, Yun-Jung Park, Hye-Jin Sohn, Chul-Ho Jung, Kyeong Cheon Park, Seong Hoe Lee, Jae-Il Lab Anim Res Case Report Intervertebral disc herniation (IVDH) with nucleus pulposus extrusion, traumatic or not, is a devastating clinical condition accompanied by neurological problems. Here we report a cynomolgus macaque suffering from acute and progressive neurological dysfunction by a blunt trauma due to neck collar, an animal handling device. Tetraplegia, urinary incontinence, decreased proprioception, and imperception of pain were shown on physical and neurological examinations. MRI sagittal T2 weighted sequences revealed an extensive protrusion of disc material between C2 and C3 cervical vertebra, and this protrusion resulted in central stenosis of the spinal cord. Histopathologic findings showed a large number of inflammatory cells infiltrated at sites of spinal cord injury (SCI). This case is the first report of compressive cervical SCI caused by IVDH associated with blunt trauma. Korean Association for Laboratory Animal Science 2016-12 2016-12-23 /pmc/articles/PMC5206234/ /pubmed/28053621 http://dx.doi.org/10.5625/lar.2016.32.4.267 Text en Copyright © 2016 Korean Association for Laboratory Animal Science http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Choi, Yun-Jung
Park, Hye-Jin
Sohn, Chul-Ho
Jung, Kyeong Cheon
Park, Seong Hoe
Lee, Jae-Il
Clinical and magnetic resonance imaging features of compressive cervical myelopathy with traumatic intervertebral disc herniation in cynomolgus macaque (Macaca fascicularis)
title Clinical and magnetic resonance imaging features of compressive cervical myelopathy with traumatic intervertebral disc herniation in cynomolgus macaque (Macaca fascicularis)
title_full Clinical and magnetic resonance imaging features of compressive cervical myelopathy with traumatic intervertebral disc herniation in cynomolgus macaque (Macaca fascicularis)
title_fullStr Clinical and magnetic resonance imaging features of compressive cervical myelopathy with traumatic intervertebral disc herniation in cynomolgus macaque (Macaca fascicularis)
title_full_unstemmed Clinical and magnetic resonance imaging features of compressive cervical myelopathy with traumatic intervertebral disc herniation in cynomolgus macaque (Macaca fascicularis)
title_short Clinical and magnetic resonance imaging features of compressive cervical myelopathy with traumatic intervertebral disc herniation in cynomolgus macaque (Macaca fascicularis)
title_sort clinical and magnetic resonance imaging features of compressive cervical myelopathy with traumatic intervertebral disc herniation in cynomolgus macaque (macaca fascicularis)
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5206234/
https://www.ncbi.nlm.nih.gov/pubmed/28053621
http://dx.doi.org/10.5625/lar.2016.32.4.267
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