Downregulation of PGC-1α Prevents the Beneficial Effect of EET-Heme Oxygenase-1 on Mitochondrial Integrity and Associated Metabolic Function in Obese Mice

Background/Objectives. Obesity and metabolic syndrome and associated adiposity are a systemic condition characterized by increased mitochondrial dysfunction, inflammation, and inhibition of antioxidant genes, HO-1, and EETs levels. We postulate that EETs attenuate adiposity by stimulating mitochondr...

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Detalles Bibliográficos
Autores principales: Singh, Shailendra P., Bellner, Lars, Vanella, Luca, Cao, Jian, Falck, John R., Kappas, Attallah, Abraham, Nader G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5206458/
https://www.ncbi.nlm.nih.gov/pubmed/28097021
http://dx.doi.org/10.1155/2016/9039754

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5206458/
https://www.ncbi.nlm.nih.gov/pubmed/28097021
http://dx.doi.org/10.1155/2016/9039754

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