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Downregulation of PGC-1α Prevents the Beneficial Effect of EET-Heme Oxygenase-1 on Mitochondrial Integrity and Associated Metabolic Function in Obese Mice

Background/Objectives. Obesity and metabolic syndrome and associated adiposity are a systemic condition characterized by increased mitochondrial dysfunction, inflammation, and inhibition of antioxidant genes, HO-1, and EETs levels. We postulate that EETs attenuate adiposity by stimulating mitochondr...

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Detalles Bibliográficos
Autores principales:	Singh, Shailendra P., Bellner, Lars, Vanella, Luca, Cao, Jian, Falck, John R., Kappas, Attallah, Abraham, Nader G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5206458/ https://www.ncbi.nlm.nih.gov/pubmed/28097021 http://dx.doi.org/10.1155/2016/9039754

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