Deubiquitinase USP13 maintains glioblastoma stem cells by antagonizing FBXL14-mediated Myc ubiquitination

Glioblastoma is the most lethal brain tumor and harbors glioma stem cells (GSCs) with potent tumorigenic capacity. The function of GSCs in tumor propagation is maintained by several core transcriptional regulators including c-Myc. c-Myc protein is tightly regulated by posttranslational modification....

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Detalles Bibliográficos
Autores principales: Fang, Xiaoguang, Zhou, Wenchao, Wu, Qiulian, Huang, Zhi, Shi, Yu, Yang, Kailin, Chen, Cong, Xie, Qi, Mack, Stephen C., Wang, Xiuxing, Carcaboso, Angel M., Sloan, Andrew E., Ouyang, Gaoliang, McLendon, Roger E., Bian, Xiu-wu, Rich, Jeremy N., Bao, Shideng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5206492/
https://www.ncbi.nlm.nih.gov/pubmed/27923907
http://dx.doi.org/10.1084/jem.20151673

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