LRCH1 interferes with DOCK8-Cdc42–induced T cell migration and ameliorates experimental autoimmune encephalomyelitis

Directional autoreactive CD4(+) T cell migration into the central nervous system plays a critical role in multiple sclerosis. Recently, DOCK8 was identified as a guanine-nucleotide exchange factor (GEF) for Cdc42 activation and has been associated with human mental retardation. Little is known about...

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Detalles Bibliográficos
Autores principales: Xu, Xiaoyan, Han, Lei, Zhao, Guixian, Xue, Shengjie, Gao, Yunzhen, Xiao, Jun, Zhang, Shicheng, Chen, Peng, Wu, Zhi-ying, Ding, Jianping, Hu, Ronggui, Wei, Bin, Wang, Hongyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5206493/
https://www.ncbi.nlm.nih.gov/pubmed/28028151
http://dx.doi.org/10.1084/jem.20160068

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