Autoinflammatory periodic fever, immunodeficiency, and thrombocytopenia (PFIT) caused by mutation in actin-regulatory gene WDR1

The importance of actin dynamics in the activation of the inflammasome is becoming increasingly apparent. IL-1β, which is activated by the inflammasome, is known to be central to the pathogenesis of many monogenic autoinflammatory diseases. However, evidence from an autoinflammatory murine model ind...

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Detalles Bibliográficos
Autores principales: Standing, Ariane S.I., Malinova, Dessislava, Hong, Ying, Record, Julien, Moulding, Dale, Blundell, Michael P., Nowak, Karolin, Jones, Hannah, Omoyinmi, Ebun, Gilmour, Kimberly C., Medlar, Alan, Stanescu, Horia, Kleta, Robert, Anderson, Glenn, Nanthapisal, Sira, Gomes, Sonia Melo, Klein, Nigel, Eleftheriou, Despina, Thrasher, Adrian J., Brogan, Paul A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5206503/
https://www.ncbi.nlm.nih.gov/pubmed/27994071
http://dx.doi.org/10.1084/jem.20161228

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