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Independent natural genetic variation of punishment- versus relief-memory

A painful event establishes two opponent memories: cues that are associated with pain onset are remembered negatively, whereas cues that coincide with the relief at pain offset acquire positive valence. Such punishment- versus relief-memories are conserved across species, including humans, and the b...

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Autores principales: Appel, Mirjam, Scholz, Claus-Jürgen, Kocabey, Samet, Savage, Sinead, König, Christian, Yarali, Ayse
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5206585/
https://www.ncbi.nlm.nih.gov/pubmed/28003518
http://dx.doi.org/10.1098/rsbl.2016.0657
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author Appel, Mirjam
Scholz, Claus-Jürgen
Kocabey, Samet
Savage, Sinead
König, Christian
Yarali, Ayse
author_facet Appel, Mirjam
Scholz, Claus-Jürgen
Kocabey, Samet
Savage, Sinead
König, Christian
Yarali, Ayse
author_sort Appel, Mirjam
collection PubMed
description A painful event establishes two opponent memories: cues that are associated with pain onset are remembered negatively, whereas cues that coincide with the relief at pain offset acquire positive valence. Such punishment- versus relief-memories are conserved across species, including humans, and the balance between them is critical for adaptive behaviour with respect to pain and trauma. In the fruit fly, Drosophila melanogaster as a study case, we found that both punishment- and relief-memories display natural variation across wild-derived inbred strains, but they do not covary, suggesting a considerable level of dissociation in their genetic effectors. This provokes the question whether there may be heritable inter-individual differences in the balance between these opponent memories in man, with potential psycho-clinical implications.
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spelling pubmed-52065852017-01-09 Independent natural genetic variation of punishment- versus relief-memory Appel, Mirjam Scholz, Claus-Jürgen Kocabey, Samet Savage, Sinead König, Christian Yarali, Ayse Biol Lett Animal Behaviour A painful event establishes two opponent memories: cues that are associated with pain onset are remembered negatively, whereas cues that coincide with the relief at pain offset acquire positive valence. Such punishment- versus relief-memories are conserved across species, including humans, and the balance between them is critical for adaptive behaviour with respect to pain and trauma. In the fruit fly, Drosophila melanogaster as a study case, we found that both punishment- and relief-memories display natural variation across wild-derived inbred strains, but they do not covary, suggesting a considerable level of dissociation in their genetic effectors. This provokes the question whether there may be heritable inter-individual differences in the balance between these opponent memories in man, with potential psycho-clinical implications. The Royal Society 2016-12 /pmc/articles/PMC5206585/ /pubmed/28003518 http://dx.doi.org/10.1098/rsbl.2016.0657 Text en © 2016 The Authors. http://creativecommons.org/licenses/by/4.0/ Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.
spellingShingle Animal Behaviour
Appel, Mirjam
Scholz, Claus-Jürgen
Kocabey, Samet
Savage, Sinead
König, Christian
Yarali, Ayse
Independent natural genetic variation of punishment- versus relief-memory
title Independent natural genetic variation of punishment- versus relief-memory
title_full Independent natural genetic variation of punishment- versus relief-memory
title_fullStr Independent natural genetic variation of punishment- versus relief-memory
title_full_unstemmed Independent natural genetic variation of punishment- versus relief-memory
title_short Independent natural genetic variation of punishment- versus relief-memory
title_sort independent natural genetic variation of punishment- versus relief-memory
topic Animal Behaviour
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5206585/
https://www.ncbi.nlm.nih.gov/pubmed/28003518
http://dx.doi.org/10.1098/rsbl.2016.0657
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