Conformational transition of FGFR kinase activation revealed by site-specific unnatural amino acid reporter and single molecule FRET

Protein kinases share significant structural similarity; however, structural features alone are insufficient to explain their diverse functions. Thus, bridging the gap between static structure and function requires a more detailed understanding of their dynamic properties. For example, kinase activa...

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Detalles Bibliográficos
Autores principales: Perdios, Louis, Lowe, Alan R., Saladino, Giorgio, Bunney, Tom D., Thiyagarajan, Nethaji, Alexandrov, Yuriy, Dunsby, Christopher, French, Paul M. W., Chin, Jason W., Gervasio, Francesco Luigi, Tate, Edward W., Katan, Matilda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5206623/
https://www.ncbi.nlm.nih.gov/pubmed/28045057
http://dx.doi.org/10.1038/srep39841

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