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Relaxation oscillations and hierarchy of feedbacks in MAPK signaling

We formulated a computational model for a MAPK signaling cascade downstream of the EGF receptor to investigate how interlinked positive and negative feedback loops process EGF signals into ERK pulses of constant amplitude but dose-dependent duration and frequency. A positive feedback loop involving...

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Detalles Bibliográficos
Autores principales:	Kochańczyk, Marek, Kocieniewski, Paweł, Kozłowska, Emilia, Jaruszewicz-Błońska, Joanna, Sparta, Breanne, Pargett, Michael, Albeck, John G., Hlavacek, William S., Lipniacki, Tomasz
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5206726/ https://www.ncbi.nlm.nih.gov/pubmed/28045041 http://dx.doi.org/10.1038/srep38244

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