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Low serum 25-hydroxyvitamin D is associated with higher risk of frequent headache in middle-aged and older men
Vitamin D has been suggested to have a role in various neurovascular diseases, but the data regarding headache is inconclusive. Our aim was to investigate the associations between serum 25-hydroxyvitamin D [25(OH)D], a marker for vitamin D status, and risk of frequent headache. The study population...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5206741/ https://www.ncbi.nlm.nih.gov/pubmed/28045039 http://dx.doi.org/10.1038/srep39697 |
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author | Virtanen, Jyrki K. Giniatullin, Rashid Mäntyselkä, Pekka Voutilainen, Sari Nurmi, Tarja Mursu, Jaakko Kauhanen, Jussi Tuomainen, Tomi-Pekka |
author_facet | Virtanen, Jyrki K. Giniatullin, Rashid Mäntyselkä, Pekka Voutilainen, Sari Nurmi, Tarja Mursu, Jaakko Kauhanen, Jussi Tuomainen, Tomi-Pekka |
author_sort | Virtanen, Jyrki K. |
collection | PubMed |
description | Vitamin D has been suggested to have a role in various neurovascular diseases, but the data regarding headache is inconclusive. Our aim was to investigate the associations between serum 25-hydroxyvitamin D [25(OH)D], a marker for vitamin D status, and risk of frequent headache. The study population consisted of 2601 men from the population-based Kuopio Ischaemic Heart Disease Risk Factor Study (KIHD) from eastern Finland, aged 42–60 years in 1984–1989. The cross-sectional associations with prevalence of self-reported frequent headache (defined as weekly or daily headaches) were estimated with multivariable-adjusted odds ratios. The average serum 25(OH) concentration was 43.4 nmol/L (SD 18.9, min-max 7.8–136.1 nmol/L). A total of 250 men (9.6%) reported frequent headache. The average serum 25(OH)D concentration among those with frequent headache was 38.3 nmol/L (SD 18.8) and 43.9 nmol/L (SD 18.9) among those without frequent headache, after adjustment for age and year and month of blood draw (P for difference <0.001). After multivariable adjustments, those in the lowest vs. the highest serum 25(OH)D quartile had 113% (95% CI 42, 218%; P for trend <0.001) higher odds for frequent headache. In conclusion, low serum 25(OH)D concentration was associated with markedly higher risk of frequent headache in men. |
format | Online Article Text |
id | pubmed-5206741 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-52067412017-01-04 Low serum 25-hydroxyvitamin D is associated with higher risk of frequent headache in middle-aged and older men Virtanen, Jyrki K. Giniatullin, Rashid Mäntyselkä, Pekka Voutilainen, Sari Nurmi, Tarja Mursu, Jaakko Kauhanen, Jussi Tuomainen, Tomi-Pekka Sci Rep Article Vitamin D has been suggested to have a role in various neurovascular diseases, but the data regarding headache is inconclusive. Our aim was to investigate the associations between serum 25-hydroxyvitamin D [25(OH)D], a marker for vitamin D status, and risk of frequent headache. The study population consisted of 2601 men from the population-based Kuopio Ischaemic Heart Disease Risk Factor Study (KIHD) from eastern Finland, aged 42–60 years in 1984–1989. The cross-sectional associations with prevalence of self-reported frequent headache (defined as weekly or daily headaches) were estimated with multivariable-adjusted odds ratios. The average serum 25(OH) concentration was 43.4 nmol/L (SD 18.9, min-max 7.8–136.1 nmol/L). A total of 250 men (9.6%) reported frequent headache. The average serum 25(OH)D concentration among those with frequent headache was 38.3 nmol/L (SD 18.8) and 43.9 nmol/L (SD 18.9) among those without frequent headache, after adjustment for age and year and month of blood draw (P for difference <0.001). After multivariable adjustments, those in the lowest vs. the highest serum 25(OH)D quartile had 113% (95% CI 42, 218%; P for trend <0.001) higher odds for frequent headache. In conclusion, low serum 25(OH)D concentration was associated with markedly higher risk of frequent headache in men. Nature Publishing Group 2017-01-03 /pmc/articles/PMC5206741/ /pubmed/28045039 http://dx.doi.org/10.1038/srep39697 Text en Copyright © 2017, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Virtanen, Jyrki K. Giniatullin, Rashid Mäntyselkä, Pekka Voutilainen, Sari Nurmi, Tarja Mursu, Jaakko Kauhanen, Jussi Tuomainen, Tomi-Pekka Low serum 25-hydroxyvitamin D is associated with higher risk of frequent headache in middle-aged and older men |
title | Low serum 25-hydroxyvitamin D is associated with higher risk of frequent headache in middle-aged and older men |
title_full | Low serum 25-hydroxyvitamin D is associated with higher risk of frequent headache in middle-aged and older men |
title_fullStr | Low serum 25-hydroxyvitamin D is associated with higher risk of frequent headache in middle-aged and older men |
title_full_unstemmed | Low serum 25-hydroxyvitamin D is associated with higher risk of frequent headache in middle-aged and older men |
title_short | Low serum 25-hydroxyvitamin D is associated with higher risk of frequent headache in middle-aged and older men |
title_sort | low serum 25-hydroxyvitamin d is associated with higher risk of frequent headache in middle-aged and older men |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5206741/ https://www.ncbi.nlm.nih.gov/pubmed/28045039 http://dx.doi.org/10.1038/srep39697 |
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