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Investigating Mutations to Reduce Huntingtin Aggregation by Increasing Htt-N-Terminal Stability and Weakening Interactions with PolyQ Domain

Huntington's disease is a fatal autosomal genetic disorder characterized by an expanded glutamine-coding CAG repeat sequence in the huntingtin (Htt) exon 1 gene. The Htt protein associated with the disease misfolds into toxic oligomers and aggregate fibril structures. Competing models for the m...

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Detalles Bibliográficos
Autores principales:	Smaoui, Mohamed R., Mazza-Anthony, Cody, Waldispühl, Jérôme
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5206856/ https://www.ncbi.nlm.nih.gov/pubmed/28096892 http://dx.doi.org/10.1155/2016/6247867

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