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Tumor suppressor genes that escape from X-inactivation contribute to cancer sex bias

There is a striking and unexplained male predominance across many cancer types. A subset of X chromosome (chrX) genes can escape X-inactivation, which would protect females from complete functional loss by a single mutation. To identify putative “Escape from X-Inactivation Tumor Suppressor” (EXITS)...

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Detalles Bibliográficos
Autores principales:	Dunford, Andrew, Weinstock, David M., Savova, Virginia, Schumacher, Steven E., Cleary, John P., Yoda, Akinori, Sullivan, Timothy J., Hess, Julian M., Gimelbrant, Alexander A., Beroukhim, Rameen, Lawrence, Michael S., Getz, Gad, Lane, Andrew A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5206905/ https://www.ncbi.nlm.nih.gov/pubmed/27869828 http://dx.doi.org/10.1038/ng.3726

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