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Electrogenic Binding of Intracellular Cations Defines a Kinetic Decision Point in the Transport Cycle of the Human Serotonin Transporter

The plasmalemmal monoamine transporters clear the extracellular space from their cognate substrates and sustain cellular monoamine stores even during neuronal activity. In some instances, however, the transporters enter a substrate-exchange mode, which results in release of intracellular substrate....

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Detalles Bibliográficos
Autores principales: Hasenhuetl, Peter S., Freissmuth, Michael, Sandtner, Walter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5207061/
https://www.ncbi.nlm.nih.gov/pubmed/27756841
http://dx.doi.org/10.1074/jbc.M116.753319