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Targeted Elimination of G Proteins and Arrestins Defines Their Specific Contributions to Both Intensity and Duration of G Protein-coupled Receptor Signaling

G protein-coupled receptors (GPCRs) can initiate intracellular signaling cascades by coupling to an array of heterotrimeric G proteins and arrestin adaptor proteins. Understanding the contribution of each of these coupling options to GPCR signaling has been hampered by a paucity of tools to selectiv...

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Detalles Bibliográficos
Autores principales:	Alvarez-Curto, Elisa, Inoue, Asuka, Jenkins, Laura, Raihan, Sheikh Zahir, Prihandoko, Rudi, Tobin, Andrew B., Milligan, Graeme
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2016
Materias:	Signal Transduction
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5207144/ https://www.ncbi.nlm.nih.gov/pubmed/27852822 http://dx.doi.org/10.1074/jbc.M116.754887

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