Cargando…
Differential Receptor Binding and Regulatory Mechanisms for the Lymphangiogenic Growth Factors Vascular Endothelial Growth Factor (VEGF)-C and -D
VEGF-C and VEGF-D are secreted glycoproteins that induce angiogenesis and lymphangiogenesis in cancer, thereby promoting tumor growth and spread. They exhibit structural homology and activate VEGFR-2 and VEGFR-3, receptors on endothelial cells that signal for growth of blood vessels and lymphatics....
Autores principales: | Davydova, Natalia, Harris, Nicole C., Roufail, Sally, Paquet-Fifield, Sophie, Ishaq, Musarat, Streltsov, Victor A., Williams, Steven P., Karnezis, Tara, Stacker, Steven A., Achen, Marc G. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Biochemistry and Molecular Biology
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5207153/ https://www.ncbi.nlm.nih.gov/pubmed/27852824 http://dx.doi.org/10.1074/jbc.M116.736801 |
Ejemplares similares
-
Plasmin Activates the Lymphangiogenic Growth Factors VEGF-C and VEGF-D
por: McColl, Bradley K., et al.
Publicado: (2003) -
The connection between lymphangiogenic signalling and prostaglandin biology: A missing link in the metastatic pathway
por: Karnezis, Tara, et al.
Publicado: (2012) -
VEGF‐D promotes pulmonary oedema in hyperoxic acute lung injury
por: Sato, Teruhiko, et al.
Publicado: (2016) -
Targeting lymphatic vessel functions through tyrosine kinases
por: Williams, Steven P, et al.
Publicado: (2010) -
The VEGF signaling pathway in cancer: the road ahead
por: Stacker, Steven A., et al.
Publicado: (2013)