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Mycobacterium tuberculosis Malate Synthase Structures with Fragments Reveal a Portal for Substrate/Product Exchange

Fragment screening and high throughput screening are complementary approaches that combine with structural biology to explore the binding capabilities of an active site. We have used a fragment-based approach on malate synthase (GlcB) from Mycobacterium tuberculosis and discovered several novel bind...

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Detalles Bibliográficos
Autores principales:	Huang, Hsiao-Ling, Krieger, Inna V., Parai, Maloy K., Gawandi, Vijay B., Sacchettini, James C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2016
Materias:	Protein Structure and Folding
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5207166/ https://www.ncbi.nlm.nih.gov/pubmed/27738104 http://dx.doi.org/10.1074/jbc.M116.750877

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