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Vitamin D deficiency and the risk of tuberculosis: a meta-analysis

BACKGROUND AND AIM: To conduct meta-analyses of all published studies on various aspects of association between vitamin D and tuberculosis (TB). METHODS: PubMed and Web of Knowledge were searched for all properly controlled studies on vitamin D and TB. Pooled odds ratio, mean difference or standardi...

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Autores principales: Huang, Shao-Jun, Wang, Xian-Hua, Liu, Zhi-Dong, Cao, Wen-Li, Han, Yi, Ma, Ai-Guo, Xu, Shao-Fa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5207333/
https://www.ncbi.nlm.nih.gov/pubmed/28096657
http://dx.doi.org/10.2147/DDDT.S79870
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author Huang, Shao-Jun
Wang, Xian-Hua
Liu, Zhi-Dong
Cao, Wen-Li
Han, Yi
Ma, Ai-Guo
Xu, Shao-Fa
author_facet Huang, Shao-Jun
Wang, Xian-Hua
Liu, Zhi-Dong
Cao, Wen-Li
Han, Yi
Ma, Ai-Guo
Xu, Shao-Fa
author_sort Huang, Shao-Jun
collection PubMed
description BACKGROUND AND AIM: To conduct meta-analyses of all published studies on various aspects of association between vitamin D and tuberculosis (TB). METHODS: PubMed and Web of Knowledge were searched for all properly controlled studies on vitamin D and TB. Pooled odds ratio, mean difference or standardized mean difference, and its corresponding 95% confidence interval were calculated with the Cochrane Review Manager 5.3. RESULTS: A significantly lower vitamin D level was found in TB patients vs controls; vitamin D deficiency (VDD) was associated with an increased risk of TB, although such an association was lacking in the African population and in the human immunodeficiency virus-infected African population. A significantly lower vitamin D level was found in human immunodeficiency virus-TB-coinfected African patients receiving antiretroviral treatment who developed TB-associated immune reconstitution inflammatory syndrome vs those who did not develop TB-associated immune reconstitution inflammatory syndrome. VDD was associated with an increased risk of developing active TB in those subjects with latent TB infection and with an increased risk of tuberculin skin test conversion/TB infection conversion, and the trend toward a lower vitamin D level in active TB patients vs latent TB infection subjects did not reach statistical significance, indicating that VDD was more likely a risk factor than a consequence of TB. This concept was further strengthened by our result that anti-TB treatment did not affect vitamin D level in TB patients receiving the treatment. CONCLUSION: Our analyses revealed an association between vitamin D and TB. VDD is more likely a risk factor for TB than its consequence. More studies are needed to determine whether vitamin D supplementation is beneficial to TB prevention and treatment.
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spelling pubmed-52073332017-01-17 Vitamin D deficiency and the risk of tuberculosis: a meta-analysis Huang, Shao-Jun Wang, Xian-Hua Liu, Zhi-Dong Cao, Wen-Li Han, Yi Ma, Ai-Guo Xu, Shao-Fa Drug Des Devel Ther Original Research BACKGROUND AND AIM: To conduct meta-analyses of all published studies on various aspects of association between vitamin D and tuberculosis (TB). METHODS: PubMed and Web of Knowledge were searched for all properly controlled studies on vitamin D and TB. Pooled odds ratio, mean difference or standardized mean difference, and its corresponding 95% confidence interval were calculated with the Cochrane Review Manager 5.3. RESULTS: A significantly lower vitamin D level was found in TB patients vs controls; vitamin D deficiency (VDD) was associated with an increased risk of TB, although such an association was lacking in the African population and in the human immunodeficiency virus-infected African population. A significantly lower vitamin D level was found in human immunodeficiency virus-TB-coinfected African patients receiving antiretroviral treatment who developed TB-associated immune reconstitution inflammatory syndrome vs those who did not develop TB-associated immune reconstitution inflammatory syndrome. VDD was associated with an increased risk of developing active TB in those subjects with latent TB infection and with an increased risk of tuberculin skin test conversion/TB infection conversion, and the trend toward a lower vitamin D level in active TB patients vs latent TB infection subjects did not reach statistical significance, indicating that VDD was more likely a risk factor than a consequence of TB. This concept was further strengthened by our result that anti-TB treatment did not affect vitamin D level in TB patients receiving the treatment. CONCLUSION: Our analyses revealed an association between vitamin D and TB. VDD is more likely a risk factor for TB than its consequence. More studies are needed to determine whether vitamin D supplementation is beneficial to TB prevention and treatment. Dove Medical Press 2016-12-28 /pmc/articles/PMC5207333/ /pubmed/28096657 http://dx.doi.org/10.2147/DDDT.S79870 Text en © 2017 Huang et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Huang, Shao-Jun
Wang, Xian-Hua
Liu, Zhi-Dong
Cao, Wen-Li
Han, Yi
Ma, Ai-Guo
Xu, Shao-Fa
Vitamin D deficiency and the risk of tuberculosis: a meta-analysis
title Vitamin D deficiency and the risk of tuberculosis: a meta-analysis
title_full Vitamin D deficiency and the risk of tuberculosis: a meta-analysis
title_fullStr Vitamin D deficiency and the risk of tuberculosis: a meta-analysis
title_full_unstemmed Vitamin D deficiency and the risk of tuberculosis: a meta-analysis
title_short Vitamin D deficiency and the risk of tuberculosis: a meta-analysis
title_sort vitamin d deficiency and the risk of tuberculosis: a meta-analysis
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5207333/
https://www.ncbi.nlm.nih.gov/pubmed/28096657
http://dx.doi.org/10.2147/DDDT.S79870
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