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Reversibility of retinal ischemia due to central retinal artery occlusion by hyperbaric oxygen
PURPOSE: Ischemic retinal damage can be reversed by hyperbaric oxygen therapy (HBOT) as long as irreversible infarction damage has not developed. However, the time window till irreversible damage develops is still unknown. The study aim was to evaluate the effect of HBOT and determine possible marke...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5207437/ https://www.ncbi.nlm.nih.gov/pubmed/28096655 http://dx.doi.org/10.2147/OPTH.S121307 |
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author | Hadanny, Amir Maliar, Amit Fishlev, Gregory Bechor, Yair Bergan, Jacob Friedman, Mony Avni, Isaac Efrati, Shai |
author_facet | Hadanny, Amir Maliar, Amit Fishlev, Gregory Bechor, Yair Bergan, Jacob Friedman, Mony Avni, Isaac Efrati, Shai |
author_sort | Hadanny, Amir |
collection | PubMed |
description | PURPOSE: Ischemic retinal damage can be reversed by hyperbaric oxygen therapy (HBOT) as long as irreversible infarction damage has not developed. However, the time window till irreversible damage develops is still unknown. The study aim was to evaluate the effect of HBOT and determine possible markers for irreversible retinal damage. MATERIALS AND METHODS: Retrospective analysis of 225 patients treated with HBOT for central retinal artery occlusion (CRAO) in 1999–2015. One hundred and twenty-eight patients fulfilled inclusion/exclusion criteria: age >18 years, symptoms <20 hours, and best-corrected visual acuity (BCVA) <0.5 logMAR. RESULTS: Time delay from symptoms to treatment was 7.8±3.8 hours. The BCVA was significantly improved after HBOT, from 2.14±0.50 to 1.61±0.78 (P<0.0001). The proportion of patients with clinically meaningful visual improvement was significantly higher in patients without cherry-red spot (CRS) compared to patients with CRS at presentation (86.0% vs 57.6%, P<0.0001). The percentage of patients with final BCVA better than 1.0 was also significantly higher in patients without CRS vs patients with CRS at presentation (61.0% vs 7.1%, P<0.0001). There was no correlation between CRS and the time from symptoms. HBOT was found to be safe, and only 5.5% of patients had minor, reversible, adverse events. CONCLUSION: HBOT is an effective treatment for non-arteritic CRAO as long as CRS has not formed. The fundus findings, rather than the time delay, should be used as a marker for irreversible damage. |
format | Online Article Text |
id | pubmed-5207437 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-52074372017-01-17 Reversibility of retinal ischemia due to central retinal artery occlusion by hyperbaric oxygen Hadanny, Amir Maliar, Amit Fishlev, Gregory Bechor, Yair Bergan, Jacob Friedman, Mony Avni, Isaac Efrati, Shai Clin Ophthalmol Original Research PURPOSE: Ischemic retinal damage can be reversed by hyperbaric oxygen therapy (HBOT) as long as irreversible infarction damage has not developed. However, the time window till irreversible damage develops is still unknown. The study aim was to evaluate the effect of HBOT and determine possible markers for irreversible retinal damage. MATERIALS AND METHODS: Retrospective analysis of 225 patients treated with HBOT for central retinal artery occlusion (CRAO) in 1999–2015. One hundred and twenty-eight patients fulfilled inclusion/exclusion criteria: age >18 years, symptoms <20 hours, and best-corrected visual acuity (BCVA) <0.5 logMAR. RESULTS: Time delay from symptoms to treatment was 7.8±3.8 hours. The BCVA was significantly improved after HBOT, from 2.14±0.50 to 1.61±0.78 (P<0.0001). The proportion of patients with clinically meaningful visual improvement was significantly higher in patients without cherry-red spot (CRS) compared to patients with CRS at presentation (86.0% vs 57.6%, P<0.0001). The percentage of patients with final BCVA better than 1.0 was also significantly higher in patients without CRS vs patients with CRS at presentation (61.0% vs 7.1%, P<0.0001). There was no correlation between CRS and the time from symptoms. HBOT was found to be safe, and only 5.5% of patients had minor, reversible, adverse events. CONCLUSION: HBOT is an effective treatment for non-arteritic CRAO as long as CRS has not formed. The fundus findings, rather than the time delay, should be used as a marker for irreversible damage. Dove Medical Press 2016-12-29 /pmc/articles/PMC5207437/ /pubmed/28096655 http://dx.doi.org/10.2147/OPTH.S121307 Text en © 2017 Hadanny et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Original Research Hadanny, Amir Maliar, Amit Fishlev, Gregory Bechor, Yair Bergan, Jacob Friedman, Mony Avni, Isaac Efrati, Shai Reversibility of retinal ischemia due to central retinal artery occlusion by hyperbaric oxygen |
title | Reversibility of retinal ischemia due to central retinal artery occlusion by hyperbaric oxygen |
title_full | Reversibility of retinal ischemia due to central retinal artery occlusion by hyperbaric oxygen |
title_fullStr | Reversibility of retinal ischemia due to central retinal artery occlusion by hyperbaric oxygen |
title_full_unstemmed | Reversibility of retinal ischemia due to central retinal artery occlusion by hyperbaric oxygen |
title_short | Reversibility of retinal ischemia due to central retinal artery occlusion by hyperbaric oxygen |
title_sort | reversibility of retinal ischemia due to central retinal artery occlusion by hyperbaric oxygen |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5207437/ https://www.ncbi.nlm.nih.gov/pubmed/28096655 http://dx.doi.org/10.2147/OPTH.S121307 |
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