A Model to Investigate Single-Strand DNA Responses in G1 Human Cells via a Telomere-Targeted, Nuclease-Deficient CRISPR-Cas9 System

DNA replication stress has the potential to compromise genomic stability and, therefore, cells have developed elaborate mechanisms to detect and resolve problems that may arise during DNA replication. The presence of single-stranded DNA (ssDNA) is often associated with DNA replication stress and ser...

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Detalles Bibliográficos
Autores principales: Crefcoeur, Remco P., Zgheib, Omar, Halazonetis, Thanos D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5207518/
https://www.ncbi.nlm.nih.gov/pubmed/28046023
http://dx.doi.org/10.1371/journal.pone.0169126

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