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Substrates and Inhibitors of SAMHD1

SAMHD1 hydrolyzes 2'-deoxynucleoside-5'-triphosphates (dNTPs) into 2'-deoxynucleosides and inorganic triphosphate products. In this paper, we evaluated the impact of 2' sugar moiety substitution for different nucleotides on being substrates for SAMHD1 and mechanisms of actions fo...

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Detalles Bibliográficos
Autores principales:	Hollenbaugh, Joseph A., Shelton, Jadd, Tao, Sijia, Amiralaei, Sheida, Liu, Peng, Lu, Xiao, Goetze, Russell W., Zhou, Longhu, Nettles, James H., Schinazi, Raymond F., Kim, Baek
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5207538/ https://www.ncbi.nlm.nih.gov/pubmed/28046007 http://dx.doi.org/10.1371/journal.pone.0169052

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