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Primary pulmonary choriocarcinoma in a male that was successfully diagnosed and treated: A case report and review of the literature
INTRODUCTION: Primary pulmonary choriocarcinoma (PPC) is extremely rare, especially in males. It is characterized by a poor response to therapy and shortened survival times. Here, we report a successful diagnosis and modified treatment for PPC in a male and a review of the literature. CASE PRESENTAT...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5207558/ https://www.ncbi.nlm.nih.gov/pubmed/28033262 http://dx.doi.org/10.1097/MD.0000000000005693 |
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author | Zhu, Ran Jia, Congwei Yan, Jie Luo, Yufeng Huo, Zhen |
author_facet | Zhu, Ran Jia, Congwei Yan, Jie Luo, Yufeng Huo, Zhen |
author_sort | Zhu, Ran |
collection | PubMed |
description | INTRODUCTION: Primary pulmonary choriocarcinoma (PPC) is extremely rare, especially in males. It is characterized by a poor response to therapy and shortened survival times. Here, we report a successful diagnosis and modified treatment for PPC in a male and a review of the literature. CASE PRESENTATION: This case report describes a 67-year-old male who was discovered to have a left pulmonary mass. The patient underwent a pulmonary lobectomy. Pathological examination showed a poorly biphasic differential tumor. Immunostaining displayed that beta-human chorionic gonadotropin (β-HCG), CD10, and GATA3 were positive, and the increase of postoperative serum β-HCG secretion was also confirmed. Systemic and genital screening was performed, but other abnormal findings were not observed. The diagnosis of PPC was confirmed. Then, the patient received 4 cycles of modified chemotherapy according the condition of his body. The patient has been alive for >13 months without recurrence, and the level of serum β-HCG has already decreased to normal. In addition to reporting this case, we have also summarized the similar previously published cases. CONCLUSIONS: Currently, there is no standard treatment for PPC. A rapid and correct diagnosis is necessary. Surgery and modified chemotherapy, based on the physical condition of the patient, may currently be the best therapy for PPC. |
format | Online Article Text |
id | pubmed-5207558 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-52075582017-01-09 Primary pulmonary choriocarcinoma in a male that was successfully diagnosed and treated: A case report and review of the literature Zhu, Ran Jia, Congwei Yan, Jie Luo, Yufeng Huo, Zhen Medicine (Baltimore) 5700 INTRODUCTION: Primary pulmonary choriocarcinoma (PPC) is extremely rare, especially in males. It is characterized by a poor response to therapy and shortened survival times. Here, we report a successful diagnosis and modified treatment for PPC in a male and a review of the literature. CASE PRESENTATION: This case report describes a 67-year-old male who was discovered to have a left pulmonary mass. The patient underwent a pulmonary lobectomy. Pathological examination showed a poorly biphasic differential tumor. Immunostaining displayed that beta-human chorionic gonadotropin (β-HCG), CD10, and GATA3 were positive, and the increase of postoperative serum β-HCG secretion was also confirmed. Systemic and genital screening was performed, but other abnormal findings were not observed. The diagnosis of PPC was confirmed. Then, the patient received 4 cycles of modified chemotherapy according the condition of his body. The patient has been alive for >13 months without recurrence, and the level of serum β-HCG has already decreased to normal. In addition to reporting this case, we have also summarized the similar previously published cases. CONCLUSIONS: Currently, there is no standard treatment for PPC. A rapid and correct diagnosis is necessary. Surgery and modified chemotherapy, based on the physical condition of the patient, may currently be the best therapy for PPC. Wolters Kluwer Health 2016-12-30 /pmc/articles/PMC5207558/ /pubmed/28033262 http://dx.doi.org/10.1097/MD.0000000000005693 Text en Copyright © 2016 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nd/4.0 This is an open access article distributed under the Creative Commons Attribution-NoDerivatives License 4.0, which allows for redistribution, commercial and non-commercial, as long as it is passed along unchanged and in whole, with credit to the author. http://creativecommons.org/licenses/by-nd/4.0 |
spellingShingle | 5700 Zhu, Ran Jia, Congwei Yan, Jie Luo, Yufeng Huo, Zhen Primary pulmonary choriocarcinoma in a male that was successfully diagnosed and treated: A case report and review of the literature |
title | Primary pulmonary choriocarcinoma in a male that was successfully diagnosed and treated: A case report and review of the literature |
title_full | Primary pulmonary choriocarcinoma in a male that was successfully diagnosed and treated: A case report and review of the literature |
title_fullStr | Primary pulmonary choriocarcinoma in a male that was successfully diagnosed and treated: A case report and review of the literature |
title_full_unstemmed | Primary pulmonary choriocarcinoma in a male that was successfully diagnosed and treated: A case report and review of the literature |
title_short | Primary pulmonary choriocarcinoma in a male that was successfully diagnosed and treated: A case report and review of the literature |
title_sort | primary pulmonary choriocarcinoma in a male that was successfully diagnosed and treated: a case report and review of the literature |
topic | 5700 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5207558/ https://www.ncbi.nlm.nih.gov/pubmed/28033262 http://dx.doi.org/10.1097/MD.0000000000005693 |
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