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Critical Size Bone Defect Healing Using Collagen–Calcium Phosphate Bone Graft Materials

The need for bone graft materials to fill bony voids or gaps that are not related to the intrinsic stability of the bone that arise due to trauma, tumors or osteolysis remains a clinically relevant and significant issue. The in vivo response of collagen–tricalcium phosphate bone graft substitutes wa...

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Detalles Bibliográficos
Autores principales: Walsh, William Robert, Oliver, Rema A., Christou, Chris, Lovric, Vedran, Walsh, Emma Rose, Prado, Gustavo R., Haider, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5207671/
https://www.ncbi.nlm.nih.gov/pubmed/28045946
http://dx.doi.org/10.1371/journal.pone.0168883
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author Walsh, William Robert
Oliver, Rema A.
Christou, Chris
Lovric, Vedran
Walsh, Emma Rose
Prado, Gustavo R.
Haider, Thomas
author_facet Walsh, William Robert
Oliver, Rema A.
Christou, Chris
Lovric, Vedran
Walsh, Emma Rose
Prado, Gustavo R.
Haider, Thomas
author_sort Walsh, William Robert
collection PubMed
description The need for bone graft materials to fill bony voids or gaps that are not related to the intrinsic stability of the bone that arise due to trauma, tumors or osteolysis remains a clinically relevant and significant issue. The in vivo response of collagen–tricalcium phosphate bone graft substitutes was evaluated in a critical size cancellous defect model in skeletally mature rabbits. While the materials were chemically virtually identical, new bone formation, implant resorption and local in vivo responses were significantly different. Differences in the in vivo response may be due, in part, collagen source and processing which influences resorption profiles. Continued improvements in processing and manufacturing techniques of collagen—tricalcium phosphate bone graft substitutes can result in osteoconductive materials that support healing of critical size bone defects even in challenging pre-clinical models.
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spelling pubmed-52076712017-01-19 Critical Size Bone Defect Healing Using Collagen–Calcium Phosphate Bone Graft Materials Walsh, William Robert Oliver, Rema A. Christou, Chris Lovric, Vedran Walsh, Emma Rose Prado, Gustavo R. Haider, Thomas PLoS One Research Article The need for bone graft materials to fill bony voids or gaps that are not related to the intrinsic stability of the bone that arise due to trauma, tumors or osteolysis remains a clinically relevant and significant issue. The in vivo response of collagen–tricalcium phosphate bone graft substitutes was evaluated in a critical size cancellous defect model in skeletally mature rabbits. While the materials were chemically virtually identical, new bone formation, implant resorption and local in vivo responses were significantly different. Differences in the in vivo response may be due, in part, collagen source and processing which influences resorption profiles. Continued improvements in processing and manufacturing techniques of collagen—tricalcium phosphate bone graft substitutes can result in osteoconductive materials that support healing of critical size bone defects even in challenging pre-clinical models. Public Library of Science 2017-01-03 /pmc/articles/PMC5207671/ /pubmed/28045946 http://dx.doi.org/10.1371/journal.pone.0168883 Text en © 2017 Walsh et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Walsh, William Robert
Oliver, Rema A.
Christou, Chris
Lovric, Vedran
Walsh, Emma Rose
Prado, Gustavo R.
Haider, Thomas
Critical Size Bone Defect Healing Using Collagen–Calcium Phosphate Bone Graft Materials
title Critical Size Bone Defect Healing Using Collagen–Calcium Phosphate Bone Graft Materials
title_full Critical Size Bone Defect Healing Using Collagen–Calcium Phosphate Bone Graft Materials
title_fullStr Critical Size Bone Defect Healing Using Collagen–Calcium Phosphate Bone Graft Materials
title_full_unstemmed Critical Size Bone Defect Healing Using Collagen–Calcium Phosphate Bone Graft Materials
title_short Critical Size Bone Defect Healing Using Collagen–Calcium Phosphate Bone Graft Materials
title_sort critical size bone defect healing using collagen–calcium phosphate bone graft materials
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5207671/
https://www.ncbi.nlm.nih.gov/pubmed/28045946
http://dx.doi.org/10.1371/journal.pone.0168883
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