CXCL10/IP-10 Neutralization Can Ameliorate Lipopolysaccharide-Induced Acute Respiratory Distress Syndrome in Rats

The role of C-X-C motif chemokine 10 (CXCL10), a pro-inflammatory factor, in the development of acute respiratory distress syndrome (ARDS) remains unclear. In this study, we explored the role of CXCL10 and the effect of CXCL10 neutralization in lipopolysaccharide (LPS)-induced ARDS in rats. The expr...

Descripción completa

Detalles Bibliográficos
Autores principales: Lang, Shan, Li, Libing, Wang, Xuning, Sun, Junping, Xue, Xinying, Xiao, Yongjiu, Zhang, Mingyue, Ao, Ting, Wang, Jianxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5207674/
https://www.ncbi.nlm.nih.gov/pubmed/28046003
http://dx.doi.org/10.1371/journal.pone.0169100
_version_ 1782490410629726208
author Lang, Shan
Li, Libing
Wang, Xuning
Sun, Junping
Xue, Xinying
Xiao, Yongjiu
Zhang, Mingyue
Ao, Ting
Wang, Jianxin
author_facet Lang, Shan
Li, Libing
Wang, Xuning
Sun, Junping
Xue, Xinying
Xiao, Yongjiu
Zhang, Mingyue
Ao, Ting
Wang, Jianxin
author_sort Lang, Shan
collection PubMed
description The role of C-X-C motif chemokine 10 (CXCL10), a pro-inflammatory factor, in the development of acute respiratory distress syndrome (ARDS) remains unclear. In this study, we explored the role of CXCL10 and the effect of CXCL10 neutralization in lipopolysaccharide (LPS)-induced ARDS in rats. The expression of CXCL10 and its receptor chemokine receptor 3(CXCR3) increased after LPS induction. Moreover, neutralization of CXCL10 ameliorated the severity of ARDS by reducing pulmonary edema, inhibiting the release of inflammatory mediators (IFN-γ, IL-6 and ICAM-1) and limiting inflammatory cells (neutrophils, macrophages, CD8+ T cells) influx into the lung, with a reduction in CXCR3 expression in neutrophils and macrophages. Therefore, CXCL10 could be a potential therapeutic target in LPS-induced ARDS.
format Online
Article
Text
id pubmed-5207674
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-52076742017-01-19 CXCL10/IP-10 Neutralization Can Ameliorate Lipopolysaccharide-Induced Acute Respiratory Distress Syndrome in Rats Lang, Shan Li, Libing Wang, Xuning Sun, Junping Xue, Xinying Xiao, Yongjiu Zhang, Mingyue Ao, Ting Wang, Jianxin PLoS One Research Article The role of C-X-C motif chemokine 10 (CXCL10), a pro-inflammatory factor, in the development of acute respiratory distress syndrome (ARDS) remains unclear. In this study, we explored the role of CXCL10 and the effect of CXCL10 neutralization in lipopolysaccharide (LPS)-induced ARDS in rats. The expression of CXCL10 and its receptor chemokine receptor 3(CXCR3) increased after LPS induction. Moreover, neutralization of CXCL10 ameliorated the severity of ARDS by reducing pulmonary edema, inhibiting the release of inflammatory mediators (IFN-γ, IL-6 and ICAM-1) and limiting inflammatory cells (neutrophils, macrophages, CD8+ T cells) influx into the lung, with a reduction in CXCR3 expression in neutrophils and macrophages. Therefore, CXCL10 could be a potential therapeutic target in LPS-induced ARDS. Public Library of Science 2017-01-03 /pmc/articles/PMC5207674/ /pubmed/28046003 http://dx.doi.org/10.1371/journal.pone.0169100 Text en © 2017 Lang et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Lang, Shan
Li, Libing
Wang, Xuning
Sun, Junping
Xue, Xinying
Xiao, Yongjiu
Zhang, Mingyue
Ao, Ting
Wang, Jianxin
CXCL10/IP-10 Neutralization Can Ameliorate Lipopolysaccharide-Induced Acute Respiratory Distress Syndrome in Rats
title CXCL10/IP-10 Neutralization Can Ameliorate Lipopolysaccharide-Induced Acute Respiratory Distress Syndrome in Rats
title_full CXCL10/IP-10 Neutralization Can Ameliorate Lipopolysaccharide-Induced Acute Respiratory Distress Syndrome in Rats
title_fullStr CXCL10/IP-10 Neutralization Can Ameliorate Lipopolysaccharide-Induced Acute Respiratory Distress Syndrome in Rats
title_full_unstemmed CXCL10/IP-10 Neutralization Can Ameliorate Lipopolysaccharide-Induced Acute Respiratory Distress Syndrome in Rats
title_short CXCL10/IP-10 Neutralization Can Ameliorate Lipopolysaccharide-Induced Acute Respiratory Distress Syndrome in Rats
title_sort cxcl10/ip-10 neutralization can ameliorate lipopolysaccharide-induced acute respiratory distress syndrome in rats
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5207674/
https://www.ncbi.nlm.nih.gov/pubmed/28046003
http://dx.doi.org/10.1371/journal.pone.0169100
work_keys_str_mv AT langshan cxcl10ip10neutralizationcanamelioratelipopolysaccharideinducedacuterespiratorydistresssyndromeinrats
AT lilibing cxcl10ip10neutralizationcanamelioratelipopolysaccharideinducedacuterespiratorydistresssyndromeinrats
AT wangxuning cxcl10ip10neutralizationcanamelioratelipopolysaccharideinducedacuterespiratorydistresssyndromeinrats
AT sunjunping cxcl10ip10neutralizationcanamelioratelipopolysaccharideinducedacuterespiratorydistresssyndromeinrats
AT xuexinying cxcl10ip10neutralizationcanamelioratelipopolysaccharideinducedacuterespiratorydistresssyndromeinrats
AT xiaoyongjiu cxcl10ip10neutralizationcanamelioratelipopolysaccharideinducedacuterespiratorydistresssyndromeinrats
AT zhangmingyue cxcl10ip10neutralizationcanamelioratelipopolysaccharideinducedacuterespiratorydistresssyndromeinrats
AT aoting cxcl10ip10neutralizationcanamelioratelipopolysaccharideinducedacuterespiratorydistresssyndromeinrats
AT wangjianxin cxcl10ip10neutralizationcanamelioratelipopolysaccharideinducedacuterespiratorydistresssyndromeinrats

Ejemplares similares