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Effects of Sleep Deprivation on Phase Synchronization as Assessed by Wavelet Phase Coherence Analysis of Prefrontal Tissue Oxyhemoglobin Signals

PURPOSE: To reveal the physiological mechanism of the decline in cognitive function after sleep deprivation, a within-subject study was performed to assess sleep deprivation effects on phase synchronization, as revealed by wavelet phase coherence (WPCO) analysis of prefrontal tissue oxyhemoglobin si...

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Autores principales: Bu, Lingguo, Zhang, Ming, Li, Jianfeng, Li, Fangyi, Liu, Heshan, Li, Zengyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5207699/
https://www.ncbi.nlm.nih.gov/pubmed/28046043
http://dx.doi.org/10.1371/journal.pone.0169279
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author Bu, Lingguo
Zhang, Ming
Li, Jianfeng
Li, Fangyi
Liu, Heshan
Li, Zengyong
author_facet Bu, Lingguo
Zhang, Ming
Li, Jianfeng
Li, Fangyi
Liu, Heshan
Li, Zengyong
author_sort Bu, Lingguo
collection PubMed
description PURPOSE: To reveal the physiological mechanism of the decline in cognitive function after sleep deprivation, a within-subject study was performed to assess sleep deprivation effects on phase synchronization, as revealed by wavelet phase coherence (WPCO) analysis of prefrontal tissue oxyhemoglobin signals. MATERIALS AND METHODS: Twenty subjects (10 male and 10 female, 25.5 ± 3.5 years old) were recruited to participate in two tests: one without sleep deprivation (group A) and the other with 24 h of sleep deprivation (group B). Before the test, each subject underwent a subjective evaluation using visual analog scales. A cognitive task was performed by judging three random numbers. Continuous recordings of the near-infrared spectroscopy (NIRS) signals were obtained from both the left and right prefrontal lobes during rest, task, and post-task periods. The WPCO of cerebral Delta [HbO(2)] signals were analyzed for these three periods for both groups A and B. RESULTS: Six frequency intervals were defined: I: 0.6–2 Hz (cardiac activity), II: 0.145–0.6 Hz (respiratory activity), III: 0.052–0.145 Hz (myogenic activity), IV: 0.021–0.052 Hz (neurogenic activity), V: 0.0095–0.021 Hz (nitric oxide related endothelial activity) and VI: 0.005–0.0095 Hz (non-nitric oxide related endothelial activity). WPCO in intervals III (F = 5.955, p = 0.02) and V (F = 4.7, p = 0.037) was significantly lower in group B than in group A at rest. During the task period, WPCO in intervals III (F = 5.175, p = 0.029) and IV (F = 4.585, p = 0.039) was significantly lower in group B compared with group A. In the post-task recovery period, the WPCO in interval III (F = 6.125, p = 0.02) was significantly lower in group B compared with group A. Reaction time was significantly prolonged, and the accuracy rate and F(1) score both declined after sleep deprivation. CONCLUSIONS: The decline in WPCO after sleep deprivation indicates reduced phase synchronization between left and right prefrontal oxyhemoglobin oscillations, which may contribute to the diminished cognitive function.
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spelling pubmed-52076992017-01-19 Effects of Sleep Deprivation on Phase Synchronization as Assessed by Wavelet Phase Coherence Analysis of Prefrontal Tissue Oxyhemoglobin Signals Bu, Lingguo Zhang, Ming Li, Jianfeng Li, Fangyi Liu, Heshan Li, Zengyong PLoS One Research Article PURPOSE: To reveal the physiological mechanism of the decline in cognitive function after sleep deprivation, a within-subject study was performed to assess sleep deprivation effects on phase synchronization, as revealed by wavelet phase coherence (WPCO) analysis of prefrontal tissue oxyhemoglobin signals. MATERIALS AND METHODS: Twenty subjects (10 male and 10 female, 25.5 ± 3.5 years old) were recruited to participate in two tests: one without sleep deprivation (group A) and the other with 24 h of sleep deprivation (group B). Before the test, each subject underwent a subjective evaluation using visual analog scales. A cognitive task was performed by judging three random numbers. Continuous recordings of the near-infrared spectroscopy (NIRS) signals were obtained from both the left and right prefrontal lobes during rest, task, and post-task periods. The WPCO of cerebral Delta [HbO(2)] signals were analyzed for these three periods for both groups A and B. RESULTS: Six frequency intervals were defined: I: 0.6–2 Hz (cardiac activity), II: 0.145–0.6 Hz (respiratory activity), III: 0.052–0.145 Hz (myogenic activity), IV: 0.021–0.052 Hz (neurogenic activity), V: 0.0095–0.021 Hz (nitric oxide related endothelial activity) and VI: 0.005–0.0095 Hz (non-nitric oxide related endothelial activity). WPCO in intervals III (F = 5.955, p = 0.02) and V (F = 4.7, p = 0.037) was significantly lower in group B than in group A at rest. During the task period, WPCO in intervals III (F = 5.175, p = 0.029) and IV (F = 4.585, p = 0.039) was significantly lower in group B compared with group A. In the post-task recovery period, the WPCO in interval III (F = 6.125, p = 0.02) was significantly lower in group B compared with group A. Reaction time was significantly prolonged, and the accuracy rate and F(1) score both declined after sleep deprivation. CONCLUSIONS: The decline in WPCO after sleep deprivation indicates reduced phase synchronization between left and right prefrontal oxyhemoglobin oscillations, which may contribute to the diminished cognitive function. Public Library of Science 2017-01-03 /pmc/articles/PMC5207699/ /pubmed/28046043 http://dx.doi.org/10.1371/journal.pone.0169279 Text en © 2017 Bu et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Bu, Lingguo
Zhang, Ming
Li, Jianfeng
Li, Fangyi
Liu, Heshan
Li, Zengyong
Effects of Sleep Deprivation on Phase Synchronization as Assessed by Wavelet Phase Coherence Analysis of Prefrontal Tissue Oxyhemoglobin Signals
title Effects of Sleep Deprivation on Phase Synchronization as Assessed by Wavelet Phase Coherence Analysis of Prefrontal Tissue Oxyhemoglobin Signals
title_full Effects of Sleep Deprivation on Phase Synchronization as Assessed by Wavelet Phase Coherence Analysis of Prefrontal Tissue Oxyhemoglobin Signals
title_fullStr Effects of Sleep Deprivation on Phase Synchronization as Assessed by Wavelet Phase Coherence Analysis of Prefrontal Tissue Oxyhemoglobin Signals
title_full_unstemmed Effects of Sleep Deprivation on Phase Synchronization as Assessed by Wavelet Phase Coherence Analysis of Prefrontal Tissue Oxyhemoglobin Signals
title_short Effects of Sleep Deprivation on Phase Synchronization as Assessed by Wavelet Phase Coherence Analysis of Prefrontal Tissue Oxyhemoglobin Signals
title_sort effects of sleep deprivation on phase synchronization as assessed by wavelet phase coherence analysis of prefrontal tissue oxyhemoglobin signals
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5207699/
https://www.ncbi.nlm.nih.gov/pubmed/28046043
http://dx.doi.org/10.1371/journal.pone.0169279
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