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Regulation of B cell fate by chronic activity of the IgE B cell receptor

IgE can trigger potent allergic responses, yet the mechanisms regulating IgE production are poorly understood. Here we reveal that IgE(+) B cells are constrained by chronic activity of the IgE B cell receptor (BCR). In the absence of cognate antigen, the IgE BCR promoted terminal differentiation of...

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Detalles Bibliográficos
Autores principales:	Yang, Zhiyong, Robinson, Marcus J, Chen, Xiangjun, Smith, Geoffrey A, Taunton, Jack, Liu, Wanli, Allen, Christopher D C
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2016
Materias:	Cell Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5207771/ https://www.ncbi.nlm.nih.gov/pubmed/27935477 http://dx.doi.org/10.7554/eLife.21238

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