Pathological TDP-43 changes in Betz cells differ from those in bulbar and spinal α-motoneurons in sporadic amyotrophic lateral sclerosis

Two nerve cells types, Betz cells in layer Vb of the primary motor neocortex and α-motoneurons of the lower brainstem and spinal cord, become involved at the beginning of the pathological cascade underlying sporadic amyotrophic lateral sclerosis (sALS). In both neuronal types, the cell nuclei forfei...

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Detalles Bibliográficos
Autores principales: Braak, Heiko, Ludolph, Albert C., Neumann, Manuela, Ravits, John, Del Tredici, Kelly
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2016
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5209403/
https://www.ncbi.nlm.nih.gov/pubmed/27757524
http://dx.doi.org/10.1007/s00401-016-1633-2

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