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Concentration of Donepezil in the Cerebrospinal Fluid of AD Patients: Evaluation of Dosage Sufficiency in Standard Treatment Strategy
Although some studies have described the pharmacokinetics and pharmacodynamics of donepezil in the peripheral compartment, studies focused on drug transport across the blood–brain barrier are still very rare. To our knowledge, the fluctuation in the cerebrospinal fluid concentration of donepezil aft...
Autores principales: | Valis, Martin, Masopust, Jiri, Vysata, Oldrich, Hort, Jakub, Dolezal, Rafael, Tomek, Jiri, Misik, Jan, Kuca, Kamil, Karasova, Jana Zdarova |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5209410/ https://www.ncbi.nlm.nih.gov/pubmed/27718143 http://dx.doi.org/10.1007/s12640-016-9672-y |
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