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Diagnostic importance of faecal markers in long-term monitoring of anti-TNF-α therapy in primary responders with Crohn’s disease
INTRODUCTION: Monitoring the response to biological treatment in Crohn’s disease (CD) is a very important element of the therapeutic optimisation. AIM: To evaluate the usefulness of measuring calprotectin, lactoferrin, and myeloperoxidase in stool as markers of long-term clinical and endoscopic resp...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Termedia Publishing House
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5209457/ https://www.ncbi.nlm.nih.gov/pubmed/28053677 http://dx.doi.org/10.5114/pg.2015.55700 |
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author | Łykowska-Szuber, Liliana Klimczak, Katarzyna Eder, Piotr Krela-Kaźmierczak, Iwona Stawczyk-Eder, Kamila Michalak, Michał Studniarek, Adam Kościński, Tomasz Szymczak, Aleksandra Linke, Krzysztof |
author_facet | Łykowska-Szuber, Liliana Klimczak, Katarzyna Eder, Piotr Krela-Kaźmierczak, Iwona Stawczyk-Eder, Kamila Michalak, Michał Studniarek, Adam Kościński, Tomasz Szymczak, Aleksandra Linke, Krzysztof |
author_sort | Łykowska-Szuber, Liliana |
collection | PubMed |
description | INTRODUCTION: Monitoring the response to biological treatment in Crohn’s disease (CD) is a very important element of the therapeutic optimisation. AIM: To evaluate the usefulness of measuring calprotectin, lactoferrin, and myeloperoxidase in stool as markers of long-term clinical and endoscopic response to anti-tumour necrosis factor α (anti-TNF) treatment in CD. MATERIAL AND METHODS: The studied group consisted of 35 CD patients treated with anti-TNF-α antibodies. Clinical activity was evaluated using Crohn’s Disease Activity Index (CDAI), and the exacerbation of endoscopic changes was evaluated using a Simple Endoscopic Score for Crohn’s Disease (SES-CD). The concentration of calprotectin, lactoferrin, and myeloperoxidase was measured using the ELISA method. All measurements were performed three times – before, after 3 months, and after a year of therapy. RESULTS: During anti-TNF treatment the concentrations of all measured faecal markers decreased significantly in relation to baseline values. We observed a significant correlation at all time-points: before the therapy, after 3 months, and 12 months after starting the therapy, between the concentration of calprotectin and SES-CD, calprotectin and CDAI, as well as between lactoferrin and SES-CD, and lactoferrin and CDAI. Myeloperoxidase correlated with both SES-CD and CDAI only after 1 year of treatment. CONCLUSIONS: Faecal calprotectin and lactoferrin are valuable markers of clinical and endoscopic activity of CD in patients treated with anti-TNF antibodies. They are useful in monitoring the response to treatment. The usefulness of myeloperoxidase in this respect remains controversial. |
format | Online Article Text |
id | pubmed-5209457 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Termedia Publishing House |
record_format | MEDLINE/PubMed |
spelling | pubmed-52094572017-01-04 Diagnostic importance of faecal markers in long-term monitoring of anti-TNF-α therapy in primary responders with Crohn’s disease Łykowska-Szuber, Liliana Klimczak, Katarzyna Eder, Piotr Krela-Kaźmierczak, Iwona Stawczyk-Eder, Kamila Michalak, Michał Studniarek, Adam Kościński, Tomasz Szymczak, Aleksandra Linke, Krzysztof Prz Gastroenterol Original Paper INTRODUCTION: Monitoring the response to biological treatment in Crohn’s disease (CD) is a very important element of the therapeutic optimisation. AIM: To evaluate the usefulness of measuring calprotectin, lactoferrin, and myeloperoxidase in stool as markers of long-term clinical and endoscopic response to anti-tumour necrosis factor α (anti-TNF) treatment in CD. MATERIAL AND METHODS: The studied group consisted of 35 CD patients treated with anti-TNF-α antibodies. Clinical activity was evaluated using Crohn’s Disease Activity Index (CDAI), and the exacerbation of endoscopic changes was evaluated using a Simple Endoscopic Score for Crohn’s Disease (SES-CD). The concentration of calprotectin, lactoferrin, and myeloperoxidase was measured using the ELISA method. All measurements were performed three times – before, after 3 months, and after a year of therapy. RESULTS: During anti-TNF treatment the concentrations of all measured faecal markers decreased significantly in relation to baseline values. We observed a significant correlation at all time-points: before the therapy, after 3 months, and 12 months after starting the therapy, between the concentration of calprotectin and SES-CD, calprotectin and CDAI, as well as between lactoferrin and SES-CD, and lactoferrin and CDAI. Myeloperoxidase correlated with both SES-CD and CDAI only after 1 year of treatment. CONCLUSIONS: Faecal calprotectin and lactoferrin are valuable markers of clinical and endoscopic activity of CD in patients treated with anti-TNF antibodies. They are useful in monitoring the response to treatment. The usefulness of myeloperoxidase in this respect remains controversial. Termedia Publishing House 2015-11-23 2016 /pmc/articles/PMC5209457/ /pubmed/28053677 http://dx.doi.org/10.5114/pg.2015.55700 Text en Copyright: © 2016 Termedia Sp. z o. o. http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license. |
spellingShingle | Original Paper Łykowska-Szuber, Liliana Klimczak, Katarzyna Eder, Piotr Krela-Kaźmierczak, Iwona Stawczyk-Eder, Kamila Michalak, Michał Studniarek, Adam Kościński, Tomasz Szymczak, Aleksandra Linke, Krzysztof Diagnostic importance of faecal markers in long-term monitoring of anti-TNF-α therapy in primary responders with Crohn’s disease |
title | Diagnostic importance of faecal markers in long-term monitoring of anti-TNF-α therapy in primary responders with Crohn’s disease |
title_full | Diagnostic importance of faecal markers in long-term monitoring of anti-TNF-α therapy in primary responders with Crohn’s disease |
title_fullStr | Diagnostic importance of faecal markers in long-term monitoring of anti-TNF-α therapy in primary responders with Crohn’s disease |
title_full_unstemmed | Diagnostic importance of faecal markers in long-term monitoring of anti-TNF-α therapy in primary responders with Crohn’s disease |
title_short | Diagnostic importance of faecal markers in long-term monitoring of anti-TNF-α therapy in primary responders with Crohn’s disease |
title_sort | diagnostic importance of faecal markers in long-term monitoring of anti-tnf-α therapy in primary responders with crohn’s disease |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5209457/ https://www.ncbi.nlm.nih.gov/pubmed/28053677 http://dx.doi.org/10.5114/pg.2015.55700 |
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