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Pulmonary Function and Arterial Stiffness in Chronic Heart Failure
Arterial stiffness contributes to heart failure and is decreased by angiotensin receptor blockers (ARBs). This cross-sectional study aimed to assess associations of lung function and ARB with arterial stiffness in patients with chronic heart failure. 354 outpatients (168 males; 186 females; 68.2 ± 7...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5209595/ https://www.ncbi.nlm.nih.gov/pubmed/28097138 http://dx.doi.org/10.1155/2016/5478394 |
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author | Li, Li Hu, Bangchuan Gong, Shijin Yu, Yihua Dai, Haiwen Yan, Jing |
author_facet | Li, Li Hu, Bangchuan Gong, Shijin Yu, Yihua Dai, Haiwen Yan, Jing |
author_sort | Li, Li |
collection | PubMed |
description | Arterial stiffness contributes to heart failure and is decreased by angiotensin receptor blockers (ARBs). This cross-sectional study aimed to assess associations of lung function and ARB with arterial stiffness in patients with chronic heart failure. 354 outpatients (168 males; 186 females; 68.2 ± 7.2 years old) with chronic heart failure were evaluated. Lung function parameters, including forced vital capacity (FVC), forced expiratory volume in 1 s (FEV(1)), and FEV(1) to FVC ratio (FEV(1)/FVC), were assessed. The cardio-ankle vascular index (CAVI) was used to estimate arterial stiffness. Unadjusted correlation analyses revealed a positive association of CAVI with ARB but not ACEI, and a negative correlation with FEV(1) (r = −0.2987, p < 0.0001). Multiple stepwise regression analyses showed that ARB and FEV1 (p < 0.0001) were independent predicting factors for CAVI. These findings suggest that reduced pulmonary function is associated with increased CAVI. Pulmonary function protection could be used to improve the prognosis in heart failure, but additional studies are necessary. |
format | Online Article Text |
id | pubmed-5209595 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-52095952017-01-17 Pulmonary Function and Arterial Stiffness in Chronic Heart Failure Li, Li Hu, Bangchuan Gong, Shijin Yu, Yihua Dai, Haiwen Yan, Jing Biomed Res Int Research Article Arterial stiffness contributes to heart failure and is decreased by angiotensin receptor blockers (ARBs). This cross-sectional study aimed to assess associations of lung function and ARB with arterial stiffness in patients with chronic heart failure. 354 outpatients (168 males; 186 females; 68.2 ± 7.2 years old) with chronic heart failure were evaluated. Lung function parameters, including forced vital capacity (FVC), forced expiratory volume in 1 s (FEV(1)), and FEV(1) to FVC ratio (FEV(1)/FVC), were assessed. The cardio-ankle vascular index (CAVI) was used to estimate arterial stiffness. Unadjusted correlation analyses revealed a positive association of CAVI with ARB but not ACEI, and a negative correlation with FEV(1) (r = −0.2987, p < 0.0001). Multiple stepwise regression analyses showed that ARB and FEV1 (p < 0.0001) were independent predicting factors for CAVI. These findings suggest that reduced pulmonary function is associated with increased CAVI. Pulmonary function protection could be used to improve the prognosis in heart failure, but additional studies are necessary. Hindawi Publishing Corporation 2016 2016-12-21 /pmc/articles/PMC5209595/ /pubmed/28097138 http://dx.doi.org/10.1155/2016/5478394 Text en |
spellingShingle | Research Article Li, Li Hu, Bangchuan Gong, Shijin Yu, Yihua Dai, Haiwen Yan, Jing Pulmonary Function and Arterial Stiffness in Chronic Heart Failure |
title | Pulmonary Function and Arterial Stiffness in Chronic Heart Failure |
title_full | Pulmonary Function and Arterial Stiffness in Chronic Heart Failure |
title_fullStr | Pulmonary Function and Arterial Stiffness in Chronic Heart Failure |
title_full_unstemmed | Pulmonary Function and Arterial Stiffness in Chronic Heart Failure |
title_short | Pulmonary Function and Arterial Stiffness in Chronic Heart Failure |
title_sort | pulmonary function and arterial stiffness in chronic heart failure |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5209595/ https://www.ncbi.nlm.nih.gov/pubmed/28097138 http://dx.doi.org/10.1155/2016/5478394 |
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