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Adaptive working memory strategy training in early Alzheimer's disease: randomised controlled trial
Background Interventions that improve cognitive function in Alzheimer's disease are urgently required. Aims To assess whether a novel cognitive training paradigm based on ‘chunking’ improves working memory and general cognitive function, and is associated with reorganisation of functional activ...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Royal College of Psychiatrists
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5209631/ https://www.ncbi.nlm.nih.gov/pubmed/27758836 http://dx.doi.org/10.1192/bjp.bp.116.182048 |
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author | Huntley, J. D. Hampshire, A. Bor, D. Owen, A. Howard, R. J. |
author_facet | Huntley, J. D. Hampshire, A. Bor, D. Owen, A. Howard, R. J. |
author_sort | Huntley, J. D. |
collection | PubMed |
description | Background Interventions that improve cognitive function in Alzheimer's disease are urgently required. Aims To assess whether a novel cognitive training paradigm based on ‘chunking’ improves working memory and general cognitive function, and is associated with reorganisation of functional activity in prefrontal and parietal cortices (trial registration: ISRCTN43007027). Method Thirty patients with mild Alzheimer's disease were randomly allocated to receive 18 sessions of 30 min of either adaptive chunking training or an active control intervention over approximately 8 weeks. Pre- and post-intervention functional magnetic resonance imaging (fMRI) scans were also conducted. Results Adaptive chunking training led to significant improvements in verbal working memory and untrained clinical measures of general cognitive function. Further, fMRI revealed a bilateral reduction in task-related lateral prefrontal and parietal cortex activation in the training group compared with controls. Conclusions Chunking-based cognitive training is a simple and potentially scalable intervention to improve cognitive function in early Alzheimer's disease. |
format | Online Article Text |
id | pubmed-5209631 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Royal College of Psychiatrists |
record_format | MEDLINE/PubMed |
spelling | pubmed-52096312017-04-20 Adaptive working memory strategy training in early Alzheimer's disease: randomised controlled trial Huntley, J. D. Hampshire, A. Bor, D. Owen, A. Howard, R. J. Br J Psychiatry Papers Background Interventions that improve cognitive function in Alzheimer's disease are urgently required. Aims To assess whether a novel cognitive training paradigm based on ‘chunking’ improves working memory and general cognitive function, and is associated with reorganisation of functional activity in prefrontal and parietal cortices (trial registration: ISRCTN43007027). Method Thirty patients with mild Alzheimer's disease were randomly allocated to receive 18 sessions of 30 min of either adaptive chunking training or an active control intervention over approximately 8 weeks. Pre- and post-intervention functional magnetic resonance imaging (fMRI) scans were also conducted. Results Adaptive chunking training led to significant improvements in verbal working memory and untrained clinical measures of general cognitive function. Further, fMRI revealed a bilateral reduction in task-related lateral prefrontal and parietal cortex activation in the training group compared with controls. Conclusions Chunking-based cognitive training is a simple and potentially scalable intervention to improve cognitive function in early Alzheimer's disease. Royal College of Psychiatrists 2017-01 /pmc/articles/PMC5209631/ /pubmed/27758836 http://dx.doi.org/10.1192/bjp.bp.116.182048 Text en © The Royal College of Psychiatrists 2017. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY) licence. |
spellingShingle | Papers Huntley, J. D. Hampshire, A. Bor, D. Owen, A. Howard, R. J. Adaptive working memory strategy training in early Alzheimer's disease: randomised controlled trial |
title | Adaptive working memory strategy training in early Alzheimer's disease: randomised controlled trial |
title_full | Adaptive working memory strategy training in early Alzheimer's disease: randomised controlled trial |
title_fullStr | Adaptive working memory strategy training in early Alzheimer's disease: randomised controlled trial |
title_full_unstemmed | Adaptive working memory strategy training in early Alzheimer's disease: randomised controlled trial |
title_short | Adaptive working memory strategy training in early Alzheimer's disease: randomised controlled trial |
title_sort | adaptive working memory strategy training in early alzheimer's disease: randomised controlled trial |
topic | Papers |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5209631/ https://www.ncbi.nlm.nih.gov/pubmed/27758836 http://dx.doi.org/10.1192/bjp.bp.116.182048 |
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