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Therapeutic Effects of Human Umbilical Cord-Derived Mesenchymal Stem Cells in Acute Lung Injury Mice
The incidence and mortality of acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) are still very high, but stem cells show some promise for its treatment. Here we found that intratracheal administration of human umbilical cord-mesenchymal stem cells (UC-MSCs) significantly improved s...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5209685/ https://www.ncbi.nlm.nih.gov/pubmed/28051154 http://dx.doi.org/10.1038/srep39889 |
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author | Zhu, Hua Xiong, Yi Xia, Yunqiu Zhang, Rong Tian, Daiyin Wang, Ting Dai, Jihong Wang, Lijia Yao, Hongbing Jiang, Hong Yang, Ke Liu, Enmei Shi, Yujun Fu, Zhou Gao, Li Zou, Lin |
author_facet | Zhu, Hua Xiong, Yi Xia, Yunqiu Zhang, Rong Tian, Daiyin Wang, Ting Dai, Jihong Wang, Lijia Yao, Hongbing Jiang, Hong Yang, Ke Liu, Enmei Shi, Yujun Fu, Zhou Gao, Li Zou, Lin |
author_sort | Zhu, Hua |
collection | PubMed |
description | The incidence and mortality of acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) are still very high, but stem cells show some promise for its treatment. Here we found that intratracheal administration of human umbilical cord-mesenchymal stem cells (UC-MSCs) significantly improved survival and attenuated the lung inflammation in lipopolysaccharide (LPS)-induced ALI mice. We also used the proteins-chip and bioinformatics to analyze interactions between UC-MSCs treatment and immune-response alternations of ALI mice. Then we demonstrated that UC-MSCs could inhibit the inflammatory response of mouse macrophage in ALI mice, as well as enhance its IL-10 expression. We provide data to support the concept that the therapeutic capacity of UC-MSCs for ALI was primarily through paracrine secretion, particularly of prostaglandin-E2 (PGE2). Furthermore, we showed that UC-MSCs might secrete a panel of factors including GM-CSF, IL-6 and IL-13 to ameliorate ALI. Our study suggested that UC-MSCs could protect LPS-induced ALI model by immune regulation and paracrine factors, indicating that UC-MSCs should be a promising strategy for ALI/ARDS. |
format | Online Article Text |
id | pubmed-5209685 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-52096852017-01-04 Therapeutic Effects of Human Umbilical Cord-Derived Mesenchymal Stem Cells in Acute Lung Injury Mice Zhu, Hua Xiong, Yi Xia, Yunqiu Zhang, Rong Tian, Daiyin Wang, Ting Dai, Jihong Wang, Lijia Yao, Hongbing Jiang, Hong Yang, Ke Liu, Enmei Shi, Yujun Fu, Zhou Gao, Li Zou, Lin Sci Rep Article The incidence and mortality of acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) are still very high, but stem cells show some promise for its treatment. Here we found that intratracheal administration of human umbilical cord-mesenchymal stem cells (UC-MSCs) significantly improved survival and attenuated the lung inflammation in lipopolysaccharide (LPS)-induced ALI mice. We also used the proteins-chip and bioinformatics to analyze interactions between UC-MSCs treatment and immune-response alternations of ALI mice. Then we demonstrated that UC-MSCs could inhibit the inflammatory response of mouse macrophage in ALI mice, as well as enhance its IL-10 expression. We provide data to support the concept that the therapeutic capacity of UC-MSCs for ALI was primarily through paracrine secretion, particularly of prostaglandin-E2 (PGE2). Furthermore, we showed that UC-MSCs might secrete a panel of factors including GM-CSF, IL-6 and IL-13 to ameliorate ALI. Our study suggested that UC-MSCs could protect LPS-induced ALI model by immune regulation and paracrine factors, indicating that UC-MSCs should be a promising strategy for ALI/ARDS. Nature Publishing Group 2017-01-04 /pmc/articles/PMC5209685/ /pubmed/28051154 http://dx.doi.org/10.1038/srep39889 Text en Copyright © 2017, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Zhu, Hua Xiong, Yi Xia, Yunqiu Zhang, Rong Tian, Daiyin Wang, Ting Dai, Jihong Wang, Lijia Yao, Hongbing Jiang, Hong Yang, Ke Liu, Enmei Shi, Yujun Fu, Zhou Gao, Li Zou, Lin Therapeutic Effects of Human Umbilical Cord-Derived Mesenchymal Stem Cells in Acute Lung Injury Mice |
title | Therapeutic Effects of Human Umbilical Cord-Derived Mesenchymal Stem Cells in Acute Lung Injury Mice |
title_full | Therapeutic Effects of Human Umbilical Cord-Derived Mesenchymal Stem Cells in Acute Lung Injury Mice |
title_fullStr | Therapeutic Effects of Human Umbilical Cord-Derived Mesenchymal Stem Cells in Acute Lung Injury Mice |
title_full_unstemmed | Therapeutic Effects of Human Umbilical Cord-Derived Mesenchymal Stem Cells in Acute Lung Injury Mice |
title_short | Therapeutic Effects of Human Umbilical Cord-Derived Mesenchymal Stem Cells in Acute Lung Injury Mice |
title_sort | therapeutic effects of human umbilical cord-derived mesenchymal stem cells in acute lung injury mice |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5209685/ https://www.ncbi.nlm.nih.gov/pubmed/28051154 http://dx.doi.org/10.1038/srep39889 |
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