Piscidin-1-analogs with double L- and D-lysine residues exhibited different conformations in lipopolysaccharide but comparable anti-endotoxin activities

To become clinically effective, antimicrobial peptides (AMPs) should be non-cytotoxic to host cells. Piscidins are a group of fish-derived AMPs with potent antimicrobial and antiendotoxin activities but limited by extreme cytotoxicity. We conjectured that introduction of cationic residue(s) at the i...

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Detalles Bibliográficos
Autores principales: Kumar, Amit, Mahajan, Mukesh, Awasthi, Bhanupriya, Tandon, Anshika, Harioudh, Munesh Kumar, Shree, Sonal, Singh, Pratiksha, Shukla, Praveen Kumar, Ramachandran, Ravishankar, Mitra, Kalyan, Bhattacharjya, Surajit, Ghosh, Jimut Kanti
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5209718/
https://www.ncbi.nlm.nih.gov/pubmed/28051162
http://dx.doi.org/10.1038/srep39925

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