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Universal and reusable virus deactivation system for respiratory protection
Aerosolized pathogens are a leading cause of respiratory infection and transmission. Currently used protective measures pose potential risk of primary/secondary infection and transmission. Here, we report the development of a universal, reusable virus deactivation system by functionalization of the...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5209731/ https://www.ncbi.nlm.nih.gov/pubmed/28051158 http://dx.doi.org/10.1038/srep39956 |
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author | Quan, Fu-Shi Rubino, Ilaria Lee, Su-Hwa Koch, Brendan Choi, Hyo-Jick |
author_facet | Quan, Fu-Shi Rubino, Ilaria Lee, Su-Hwa Koch, Brendan Choi, Hyo-Jick |
author_sort | Quan, Fu-Shi |
collection | PubMed |
description | Aerosolized pathogens are a leading cause of respiratory infection and transmission. Currently used protective measures pose potential risk of primary/secondary infection and transmission. Here, we report the development of a universal, reusable virus deactivation system by functionalization of the main fibrous filtration unit of surgical mask with sodium chloride salt. The salt coating on the fiber surface dissolves upon exposure to virus aerosols and recrystallizes during drying, destroying the pathogens. When tested with tightly sealed sides, salt-coated filters showed remarkably higher filtration efficiency than conventional mask filtration layer, and 100% survival rate was observed in mice infected with virus penetrated through salt-coated filters. Viruses captured on salt-coated filters exhibited rapid infectivity loss compared to gradual decrease on bare filters. Salt-coated filters proved highly effective in deactivating influenza viruses regardless of subtypes and following storage in harsh environmental conditions. Our results can be applied in obtaining a broad-spectrum, airborne pathogen prevention device in preparation for epidemic and pandemic of respiratory diseases. |
format | Online Article Text |
id | pubmed-5209731 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-52097312017-01-05 Universal and reusable virus deactivation system for respiratory protection Quan, Fu-Shi Rubino, Ilaria Lee, Su-Hwa Koch, Brendan Choi, Hyo-Jick Sci Rep Article Aerosolized pathogens are a leading cause of respiratory infection and transmission. Currently used protective measures pose potential risk of primary/secondary infection and transmission. Here, we report the development of a universal, reusable virus deactivation system by functionalization of the main fibrous filtration unit of surgical mask with sodium chloride salt. The salt coating on the fiber surface dissolves upon exposure to virus aerosols and recrystallizes during drying, destroying the pathogens. When tested with tightly sealed sides, salt-coated filters showed remarkably higher filtration efficiency than conventional mask filtration layer, and 100% survival rate was observed in mice infected with virus penetrated through salt-coated filters. Viruses captured on salt-coated filters exhibited rapid infectivity loss compared to gradual decrease on bare filters. Salt-coated filters proved highly effective in deactivating influenza viruses regardless of subtypes and following storage in harsh environmental conditions. Our results can be applied in obtaining a broad-spectrum, airborne pathogen prevention device in preparation for epidemic and pandemic of respiratory diseases. Nature Publishing Group 2017-01-04 /pmc/articles/PMC5209731/ /pubmed/28051158 http://dx.doi.org/10.1038/srep39956 Text en Copyright © 2017, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Quan, Fu-Shi Rubino, Ilaria Lee, Su-Hwa Koch, Brendan Choi, Hyo-Jick Universal and reusable virus deactivation system for respiratory protection |
title | Universal and reusable virus deactivation system for respiratory protection |
title_full | Universal and reusable virus deactivation system for respiratory protection |
title_fullStr | Universal and reusable virus deactivation system for respiratory protection |
title_full_unstemmed | Universal and reusable virus deactivation system for respiratory protection |
title_short | Universal and reusable virus deactivation system for respiratory protection |
title_sort | universal and reusable virus deactivation system for respiratory protection |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5209731/ https://www.ncbi.nlm.nih.gov/pubmed/28051158 http://dx.doi.org/10.1038/srep39956 |
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