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Detailed simulation of cancer exome sequencing data reveals differences and common limitations of variant callers
BACKGROUND: Next-generation sequencing of matched tumor and normal biopsy pairs has become a technology of paramount importance for precision cancer treatment. Sequencing costs have dropped tremendously, allowing the sequencing of the whole exome of tumors for just a fraction of the total treatment...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5209852/ https://www.ncbi.nlm.nih.gov/pubmed/28049408 http://dx.doi.org/10.1186/s12859-016-1417-7 |