Checkpoint kinase inhibitor AZD7762 strongly sensitises urothelial carcinoma cells to gemcitabine

BACKGROUND: More effective chemotherapies are urgently needed for bladder cancer, a major cause of morbidity and mortality worldwide. We therefore explored the efficacy of the combination of gemcitabine and AZD7762, a checkpoint kinase 1/2 (CHK1/2) inhibitor, for bladder cancer. METHODS: Viability,...

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Detalles Bibliográficos
Autores principales: Isono, Makoto, Hoffmann, Michèle J., Pinkerneil, Maria, Sato, Akinori, Michaelis, Martin, Cinatl, Jindrich, Niegisch, Günter, Schulz, Wolfgang A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5209915/
https://www.ncbi.nlm.nih.gov/pubmed/28049532
http://dx.doi.org/10.1186/s13046-016-0473-1

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