Cargando…

Inhibition of placental mTOR signaling provides a link between placental malaria and reduced birthweight

BACKGROUND: Placental Plasmodium falciparum malaria can trigger intervillositis, a local inflammatory response more strongly associated with low birthweight than placental malaria infection alone. Fetal growth (and therefore birthweight) is dependent on placental amino acid transport, which is impai...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dimasuay, Kris Genelyn, Aitken, Elizabeth H., Rosario, Fredrick, Njie, Madi, Glazier, Jocelyn, Rogerson, Stephen J., Fowkes, Freya J. I., Beeson, James G., Powell, Theresa, Jansson, Thomas, Boeuf, Philippe
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5209943/ https://www.ncbi.nlm.nih.gov/pubmed/28049467 http://dx.doi.org/10.1186/s12916-016-0759-3

Ejemplares similares

Impaired placental autophagy in placental malaria
por: Dimasuay, Kris Genelyn, et al.
Publicado: (2017)

Placental Responses to Changes in the Maternal Environment Determine Fetal Growth
por: Dimasuay, Kris Genelyn, et al.
Publicado: (2016)

Maternal Protein Restriction in the Rat Inhibits Placental Insulin, mTOR, and STAT3 Signaling and Down-Regulates Placental Amino Acid Transporters
por: Rosario, Fredrick J., et al.
Publicado: (2011)

Diet‐induced obesity in mice reduces placental efficiency and inhibits placental mTOR signaling
por: Lager, Susanne, et al.
Publicado: (2014)

Maternal folate deficiency causes inhibition of mTOR signaling, down-regulation of placental amino acid transporters and fetal growth restriction in mice
por: Rosario, Fredrick J., et al.
Publicado: (2017)

Relevant Assay to Study the Adhesion of Plasmodium falciparum-Infected Erythrocytes to the Placental Epithelium
por: Boeuf, Philippe, et al.
Publicado: (2011)

Placental Remote Control of Fetal Metabolism: Trophoblast mTOR Signaling Regulates Liver IGFBP-1 Phosphorylation and IGF-1 Bioavailability
por: Rosario, Fredrick J., et al.
Publicado: (2023)

Plasmodium falciparum Malaria Elicits Inflammatory Responses that Dysregulate Placental Amino Acid Transport
por: Boeuf, Philippe, et al.
Publicado: (2013)

Placental Adaptation: What Can We Learn from Birthweight:Placental Weight Ratio?
por: Hayward, Christina E., et al.
Publicado: (2016)

Increased placental nutrient transport in a novel mouse model of maternal obesity with fetal overgrowth
por: Rosario, Fredrick J, et al.
Publicado: (2015)

Maternal obesity alters the placental transcriptome in a fetal sex-dependent manner
por: Kelly, Amy, et al.
Publicado: (2023)

Mechanistic target of rapamycin (mTOR) regulates trophoblast folate uptake by modulating the cell surface expression of FR-α and the RFC
por: Rosario, Fredrick J., et al.
Publicado: (2016)

Fetal sex differences in placental LCPUFA ether and plasmalogen phosphatidylethanolamine and phosphatidylcholine contents in pregnancies complicated by obesity
por: Powell, Theresa L., et al.
Publicado: (2023)

Placental multi-omics integration identifies candidate functional genes for birthweight
por: Tekola-Ayele, Fasil, et al.
Publicado: (2022)

Effect of a High-Fat Diet and Metformin on Placental mTOR Signaling in Mice
por: Grace, Matthew R., et al.
Publicado: (2019)

Placental mTOR Signaling and Sexual Dimorphism in Metabolic Health across the Lifespan of Offspring
por: Beetch, Megan, et al.
Publicado: (2021)

Impact of placental mTOR deficiency on peripheral insulin signaling in adult mice offspring
por: Beetch, Megan, et al.
Publicado: (2023)

Reduced risk of placental parasitemia associated with complement fixation on Plasmodium falciparum by antibodies among pregnant women
por: Opi, D. Herbert, et al.
Publicado: (2021)

Does Malaria Affect Placental Development? Evidence from In Vitro Models
por: Umbers, Alexandra J., et al.
Publicado: (2013)

Correction: Does Malaria Affect Placental Development? Evidence from In Vitro Models
por: Umbers, Alexandra J., et al.
Publicado: (2013)

Increased ubiquitination and reduced plasma membrane trafficking of placental amino acid transporter SNAT-2 in human IUGR
por: Chen, Yi-Yung, et al.
Publicado: (2015)

Placental (13)C-DHA metabolism and relationship with maternal BMI, glycemia and birthweight
por: Watkins, Oliver C., et al.
Publicado: (2021)

Placental mTOR complex 1 regulates fetal programming of obesity and insulin resistance in mice
por: Akhaphong, Brian, et al.
Publicado: (2021)

Tadalafil Treatment of Mice with Fetal Growth Restriction and Preeclampsia Improves Placental mTOR Signaling
por: Tanaka, Kayo, et al.
Publicado: (2022)

Reduction of In Vivo Placental Amino Acid Transport Precedes the Development of Intrauterine Growth Restriction in the Non-Human Primate
por: Rosario, Fredrick J., et al.
Publicado: (2021)

Down-Regulation of Placental Transport of Amino Acids Precedes the Development of Intrauterine Growth Restriction in Maternal Nutrient Restricted Baboons
por: Pantham, Priyadarshini, et al.
Publicado: (2016)

Maximizing antimalarial efficacy and the importance of dosing strategies
por: Beeson, James G, et al.
Publicado: (2015)

SUN-635 Profiling of Activation Patterns of Placental mTOR in Pregnancies Complicated by Gestational Diabetes Mellitus
por: Papadopoulou, Anna, et al.
Publicado: (2020)

Genetically-predicted placental gene expression is associated with birthweight and adult body mass index
por: Jasper, Elizabeth A., et al.
Publicado: (2023)

Comparison of the ratio of placental territory discordance to birthweight discordance in placentas of monochorionic diamniotic twins
por: Xueju, Wang, et al.
Publicado: (2021)

Preconceptional Lipid-Based Nutrient Supplementation in 2 Low-Resource Countries Results in Distinctly Different IGF-1/mTOR Placental Responses
por: Castillo-Castrejon, Marisol, et al.
Publicado: (2020)

Tollip interaction with STAT3: a novel mechanism to regulate human airway epithelial responses to type 2 cytokines
por: Schaunaman, Niccolette, et al.
Publicado: (2022)

Role of Myeloid Cell-Specific TLR9 in Mitochondrial DNA-Induced Lung Inflammation in Mice
por: Dimasuay, Kris Genelyn, et al.
Publicado: (2023)

Placental Nutrient Transport in Gestational Diabetic Pregnancies
por: Castillo-Castrejon, Marisol, et al.
Publicado: (2017)

Diagnosis of placental malaria in poorly fixed and processed placental tissue
por: Liu, Yunhao, et al.
Publicado: (2016)

Hypoxia reduces placental mTOR activation in a hypoxia‐induced model of intrauterine growth restriction (IUGR)
por: Kimball, Rebecca, et al.
Publicado: (2015)

New Hosts of Simplicimonas similis and Trichomitus batrachorum Identified by 18S Ribosomal RNA Gene Sequences
por: Dimasuay, Kris Genelyn B., et al.
Publicado: (2013)

Corrigendum: Placental Nutrient Transport in Gestational Diabetic Pregnancies
por: Castillo-Castrejon, Marisol, et al.
Publicado: (2019)

Tadalafil Treatment Ameliorates Hypoxia and Alters Placental Expression of Proteins Downstream of mTOR Signaling in Fetal Growth Restriction
por: Tsuchiya, Kyoka, et al.
Publicado: (2020)

Placental weight and birthweight: the relations with number of daily cigarettes and smoking cessation in pregnancy. A population study
por: Larsen, Sandra, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_3uof03lpcdve73rfj5hgfinfaq